HOW I DO IT A Novel Image-Guided Surgery of Hepatocellular Carcinoma by Indocyanine Green Fluorescence Imaging Navigation
HOW I DO IT A Novel Image-Guided Surgery of Hepatocellular Carcinoma by Indocyanine Green Fluorescence Imaging Navigation
复制标题
DOI：
10.1002/jso.21272
复制
发表时间：
2009-07-01
影响因子：
2.5
通讯作者：
Imaoka, Shingi
中科院分区：
文献类型：
--
作者：
Gotoh, Kunihito;Yamada, Terumasa;Imaoka, Shingi
背景和目的：肿瘤和正常组织之间的清晰分界是实时手术导航成像的理想选择。我们提出了一种新的吲哚菁绿色（ICG）荧光成像技术，可视化肝细胞癌（HCC）hepatocellular carcinoma hepatocellular在手术前几天以0.5 mg/kg体重的剂量静脉注射ICG。剖腹手术后，用术中超声（IOUS）检查肝脏，然后用近红外（NIR）荧光成像系统（PDE; Hamamatsu Photonics K.K.结果：10例原发性肿瘤均显示明亮的荧光信号，在PDE引导下可完全切除，切缘阴性。在4例病例（40.0%）中，PDE检测到了未通过使用任何术前检查（包括IOUS）检测到的新HCC结节。这些新发现的肝癌结节是非常小的尺寸和肿瘤的分化良好的HCCs.Conclusions：这种新的技术是简单和安全的，因此被认为是一个有前途的工具，在常规的术中成像肝切除术和进一步的临床探索肝癌。外科肿瘤学杂志2009; 100：75-79. (C)2009 Wiley-Liss，Inc.
Background and Objectives: The clear delineation between tumor and normal tissue is ideal for real-time surgical navigation imaging. We present a novel indocyanine green (ICG) fluorescence imaging technique to visualize hepatocellular carcinoma (HCC).Methods: Ten patients with solitary HCC underwent hepatectomy between February and September 2007 at Osaka Medical Center for Cancer and Cardiovascular Diseases. ICG had been injected intravenously several clays before Surgery at a dose of 0.5 mg/kg body weight. After laparotomy, the liver was inspected with intraoperative ultrasonography (IOUS), and then With a near-infrared (NIR) fluorescence imaging system (PDE; Hamamatsu Photonics K.K. Hamamatsu, Japan).Results: All the 10 primary tumors showed bright fluorescent signals and Could be completely removed with negative margins under the guide of PDE. In four cases (40.0%), new HCC nodules that were not detected by use of any preoperative examinations including IOUS were detected by PDE. These newly identified HCC nodules Were very small in size and most of the tumors were well-differentiated HCCs.Conclusions: This novel technique is simple and safe, and is therefore considered to be a promising tool for routine intraoperative imaging during a hepatic resection and further clinical exploration for HCC. J. Surg. Oncol. 2009; 100: 75-79. (C) 2009 Wiley-Liss, Inc.