CATECHOLAMINES AND COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES
CATECHOLAMINES AND COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES
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DOI：
10.1111/j.1749-6632.1985.tb37592.x
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发表时间：
1985-01-01
影响因子：
5.2
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
--
作者：
ARNSTEN, AFT;GOLDMANRAKIC, PS
讨论儿茶酚胺丢失在老年非人类灵长类动物表现出的认知衰退中的作用，这些灵长类动物的认知缺陷类似于人类的正常衰老。多年来，啮齿动物大脑皮质中儿茶酚胺的分布已为人所知。多巴胺细胞选择性地投射到前额叶和前扣带回区域，而去甲肾上腺素能细胞统一投射到所有皮质区域。猕猴的前额叶皮质广泛地与海马体、杏仁核、丘脑背内侧核、蓝斑和基底核相互联系。由于与记忆功能有关的许多结构都有联系，因此前额叶皮质的几个区域是两种空间记忆任务正常执行的关键焦点就不足为奇了：空间延迟反应任务和延迟交替任务。在老年猴子身上出现的认知障碍模式与背侧前额叶皮质损伤所产生的模式有显著的相似之处。讨论了阿尔茨海默病治疗的意义。(参考文献49)(心理信息数据库记录(C)2016 APA，保留所有权利)
Discusses the role of catecholamine loss in the cognitive decline exhibited by aged nonhuman primates whose cognitive deficits resemble those associated with normal aging in humans. The distribution of catecholamines in the cortex of the rodent brain has been known for many years. Dopamine cells project selectively to the prefrontal and anterior cingulate regions, whereas noradrenergic cells project uniformly to all cortical areas. The prefrontal cortex in monkeys is extensively interconnected with the hippocampus, amygdala, dorsomedial thalamus, locus coeruleus, and nucleus basalis. With connections to so many structures implicated in memory function, it is not surprising that several areas of prefrontal cortex are critical foci for normal performance of 2 spatial memory tasks: the spatial delayed response and delayed alternation tasks. The pattern of cognitive impairment that develops in aged monkeys bears a marked resemblance to that produced by lesions to the dorsolateral prefrontal cortex. Implications for the treatment of Alzheimer's disease are discussed.(49 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)