Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample
Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample
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DOI：
10.1016/j.biopsych.2005.08.015
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发表时间：
2006-01-15
影响因子：
10.6
通讯作者：
Gurling, HMD
中科院分区：
文献类型：
--
作者：
Puri, V;McQuillin, A;Gurling, HMD
背景：连锁研究已经证实染色体1q23.3是精神分裂症的易感基因。然后声称，标记在羧基末端PDZ配体的神经元型一氧化氮合酶（CAPON）基因显示等位基因与精神分裂症在加拿大的家庭。第二个中国的研究发现CAPON基因的碱基对多态性也与精神分裂症有关。方法：我们尝试使用来自加拿大研究的8个标记在英国的450例病例和450例超常对照的样本中进行复制。结果：我们没有发现在加拿大样本中发现的任何标记与精神分裂症相关的等位基因或单倍型相关的证据。结论：阴性结果可能反映了加拿大、中国和英国样本之间的遗传异质性，或者是由于方法学问题。目前的发现削弱了CATON基因突变或变异导致欧洲人群对精神分裂症遗传易感性的证据。
Background: Linkage studies have confirmed that chromosome 1q23.3 is a susceptibility locus for schizophrenia. It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families. A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia.Methods: We attempted replication using eight markers from the Canadian study in a UK based sample of 450 cases and 450 supernormal controls.Results: We found no evidence for allelic or haplotypic association with schizophrenia for any of the markers found to be associated in the Canadian sample.Conclusions: The negative results might reflect genetic heterogeneity between the Canadian, Chinese and UK samples or be due to methodological problems. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.