Fetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination
Fetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination
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DOI：
10.1007/s00381-003-0767-4
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发表时间：
2003-08-01
影响因子：
1.4
通讯作者：
Sebag, G
中科院分区：
文献类型：
--
作者：
Garel, C;Chantrel, E;Sebag, G
目的：直到过去10年，正常的大脑妊娠标志进行了评估超声和胎儿病理学研究。本文的目的是显示胎儿MRI提供的可能性，在评估胎儿脑生物学，正常脑沟和髓鞘形成。方法：使用标准化方法对225例胎儿（大脑正常）进行前瞻性研究。胎龄22 ~ 38周。给出了这些时期各种脑结构的生物统计学主要数据。讨论内容：与超声相反，MRI允许测量大脑（而不是头骨），这与胎儿头部的位置无关。不同脑沟出现的时间也可以通过MRI得到。它被认为是胎儿大脑成熟的良好标志物。与髓鞘形成同时发生的生物化学变化使得使用MRI评估胎儿脑中的这种现象成为可能。
Purpose: Up until the last 10 years, normal cerebral gestational landmarks were assessed by ultrasonographic and fetopathologic studies. The purpose of this paper is to display the possibilities provided by fetal MRI in the evaluation of fetal cerebral biometry, normal sulcation and myelination. Methods: Two hundred and twenty-five fetuses (with a normal brain) were studied prospectively using a standardised method. The gestational age ranged from 22 to 38 weeks. The main data concerning biometry of various cerebral structures at those terms are given. Discussion: In contrast to ultrasound, MRI allows measurements of brain (and not skull), which are available independently of the position of the fetal head. The timing of the appearance of the different sulci is also available using MRI. It is considered to be a good marker of fetal brain maturation. The biochemical modifications contemporary to myelination make it possible to evaluate this phenomenon in the fetal brain using MRI.