Eruptive melanocytic nevi in patients with renal allografts: Report of 10 cases with dermoscopic findings
Eruptive melanocytic nevi in patients with renal allografts: Report of 10 cases with dermoscopic findings
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DOI：
10.1016/s0190-9622(03)02482-4
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发表时间：
2003-12-01
影响因子：
13.8
通讯作者：
Belloni-Fortina, A
中科院分区：
文献类型：
--
作者：
Alaibac, M;Piaserico, S;Belloni-Fortina, A
据报道，在肾同种异体移植后，特别是在儿童和青少年中，发生了发疹性痣，并且免疫抑制被认为有利于良性和恶性黑素细胞增殖。在这项研究中，我们描述了10名儿童，青少年和年轻的成人与肾移植的多发性黑色素细胞痣在移植后短期内发展的发疹性黑色素细胞痣的皮肤镜特征。发疹性色素性病变的皮肤镜检查显示棕色小球的外周边缘。80%的发疹性痣患者和同一患者的大多数病变中存在这种边缘的外周小球。黑素细胞痣的其他标准皮肤镜检查标准正常。在我们的研究中，我们证实了以前的报告有关的发展，发疹痣的儿童和青少年接受免疫抑制治疗。特别是，我们通过皮肤镜检查发现存在特征性对称边缘的外周棕色小球。这一发现与以下假设相一致，即对称的外周边缘的小球可能表明快速扩大的黑素细胞病变。此外，我们已经确定了一组新的患者，其特点是这种皮肤镜的功能。这些患者是接受免疫抑制治疗的儿童、青少年和年轻人，这种皮肤镜特征可能在与任何原因的免疫抑制相关的发疹性痣中发现。
Eruptive nevi have been reported after renal allograft transplantation, particularly in children and adolescents, and immunosuppresion has been Suggested to favor both benign and malignant melanocyte proliferation. In this study, we describe the dermoscopic features of eruptive melanocytic nevi in 10 children, adolescents, and young adults with renal allografts in whom multiple melanocytic nevi developed during a short period after transplantation. Dermoscopy of the eruptive pigmented lesions revealed a peripheral rim of brown globules. This rim of peripheral globules was present in 80% of the patients with eruptive nevi and in most of the lesions of the same patient. The other standard dermoscopic criteria for melanocytic nevi were normal. In our study, we confirm previous reports concerning the development of eruptive nevi in children and adolescents receiving immunosuppressive therapies. In particular, we showed by dermoscopy the presence of a characteristic symmetrical rim of peripheral brown globules. This finding is consistent with the hypothesis that a symmetrical peripheral rim of globules may indicate rapid enlargement of melanocytic lesions. Moreover, we have identified a new group of patients characterized by this dermoscopic feature. These patients are children, adolescents, and young adults with renal allografts receiving immunosuppressive therapy and it is plausible that this dermoscopic characteristic may be found in eruptive nevi developed in association with immunosuppression from any cause.