Central nervous system pericytes in health and disease.
Central nervous system pericytes in health and disease.
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DOI：
10.1038/nn.2946
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发表时间：
2011-10-26
影响因子：
25
通讯作者：
Zlokovic BV
中科院分区：
文献类型：
--
作者：
Winkler EA;Bell RD;Zlokovic BV
周细胞独特地位于神经血管单元内，以充当许多神经血管功能的重要整合剂、协调剂和效应剂，所述神经血管功能包括血管生成、血脑屏障（BBB）形成和维持、血管稳定性和血管结构、毛细血管血流的调节以及适当CNS稳态和神经元功能所必需的有毒细胞副产物的清除。新的研究表明，中枢神经系统中周细胞缺乏导致血脑屏障破坏和脑灌注不足，从而导致继发性神经退行性变化。在这里，我们回顾了最近的进展，了解中枢神经系统周细胞的生物学及其在健康和疾病中的作用。
Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators, coordinators and effectors of many neurovascular functions, including angiogenesis, blood-brain barrier (BBB) formation and maintenance, vascular stability and angioarchitecture, regulation of capillary blood flow and clearance of toxic cellular byproducts necessary for proper CNS homeostasis and neuronal function. New studies have revealed that pericyte deficiency in the CNS leads to BBB breakdown and brain hypoperfusion resulting in secondary neurodegenerative changes. Here we review recent progress in understanding the biology of CNS pericytes and their role in health and disease.