Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents
Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents
复制标题
DOI：
10.1093/ajcn/86.1.150
复制
发表时间：
2007-07-01
影响因子：
7.1
通讯作者：
Zemel, Babette S.
中科院分区：
文献类型：
--
作者：
Weng, Francis L.;Shults, Justine;Zemel, Babette S.
背景：血清25-羟基维生素D [25（OH）D]浓度作为维生素D储存的生物标志物。以前的研究没有检查的风险因素低维生素D浓度在一个多种族的美国青年样品在广泛的年龄范围。Objective：目的是确定的患病率和相关因素与低浓度的25（OH）D在儿童和adolescents.Design：血清25（OH）D浓度测定在382名健康儿童年龄6-21 y生活在美国东北部。饮食和补充维生素D的摄入量通过访谈进行评估。通过双能X线吸收法评估脂肪和瘦体重。多变量有序逻辑回归用于确定与25（OH）D浓度降低相关的因素。结果：25（OH）D的中位浓度为28 ng/mL（四分位数范围：19-35 ng/mL），55%的受试者25（OH）D浓度< 30 ng/mL。25（OH）D浓度与甲状旁腺激素浓度呈负相关（斯皮尔曼r =-0.31，P < 0.001），但与1，25-二羟维生素D浓度无显著相关性。在多变量模型中，（P < 0.001），黑人[比值比（OR）：14.2; 95% CI：8.53，23.5]，冬季研究访视（OR：3.55; 95%CI：2.29，5.50）和每日维生素D总摄入量< 200 IU（OR：1.58; 95%CI：1.02，2.46）与低维生素D浓度相关。脂肪和瘦体重与维生素D的状态，在这个healthy-weight samples.Conclusion：低血清25（OH）D浓度普遍存在于其他健康的儿童和青少年在美国东北部和低维生素D摄入量，种族和季节。
Background: Serum 25-hydroxyvitamin D [25(OH)D] concentrations serve as a biomarker for vitamin D stores. Prior studies have not examined the risk factors for low vitamin D concentrations in a multiethnic sample of US youth across a broad age range.Objective: The objective was to determine the prevalence of and factors associated with low concentrations of 25(OH)D in children and adolescents.Design: Serum 25(OH)D concentrations were measured in 382 healthy children aged 6-21 y living in the northeastern United States. Dietary and supplemental vitamin D intake was assessed by interview. Fat and lean mass were assessed by dual-energy X-ray absorptiometry. Multivariable ordinal logistic regression was used to determine factors associated with decreased concentrations of 25(OH)D.Results: The median concentration of 25(OH)D was 28 ng/mL (interquartile range: 19-35 ng/mL), and 55% of subjects had 25(OH)D concentrations < 30 ng/mL. 25(OH)D concentrations were inversely correlated with parathyroid hormone concentrations (Spearman's r = -0.31, P < 0.001) but were not significantly correlated with 1,25-dihydroxyvitamin D concentrations. In the multivariable model, older age (P < 0.001), black race [odds ratio (OR): 14.2; 95% CI: 8.53, 23.5], wintertime study visit (OR: 3.55; 95% CI: 2.29, 5.50), and total daily vitamin D intake < 200 IU (OR: 1.58; 95% CI: 1.02, 2.46) were associated with low vitamin D concentrations. Fat and lean mass were not independently associated with vitamin D status in this healthy-weight sample.Conclusion: Low serum 25(OH)D concentrations are prevalent in otherwise healthy children and adolescents in the northeastern United States and are related to low vitamin D intake, race, and season.