Organochlorine pesticides in follicular fluid of women undergoing assisted reproductive technologies from central China.
Organochlorine pesticides in follicular fluid of women undergoing assisted reproductive technologies from central China.
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DOI：
10.1016/j.envpol.2015.09.030
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发表时间：
2015-12
影响因子：
8.9
通讯作者：
Yindi Zhu;Bo Huang;Qing X. Li;Jun Wang
中科院分区：
文献类型：
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作者：
Yindi Zhu;Bo Huang;Qing X. Li;Jun Wang
自20世纪80年代以来，女性不孕率增加了约4%。近年来有证据表明，接触化学污染对女性生育能力有不利影响。收集了127名接受辅助生殖技术（ART）且无职业接触OCPs记录的女性患者（年龄在20-35岁）的卵泡液样本。本研究分析了17例ocp。结果表明，甲氧基氯居多，占总ocp的13.4%，平均浓度为167.9±33.9 ng/g脂质质量（lw），其次为环氧七氯、六氯环己烷、endrin和DDT。本研究中卵泡液样本中ocp的浓度与发达国家或工业化国家的报告相比是中等的。所有这些污染物都可以通过饮食、饮水和呼吸在人体的不同组织中积累。本研究未观察到患者年龄与OCP浓度之间的相关性。
Female infertility rates have increased by approximately 4% since the 1980s. There is evidence of adverse effects on female fertility in relation to exposure of chemical pollution in recent years. Follicular fluid samples were collected from 127 woman patients (aged 20–35) who underwent assisted reproductive technologies (ART) and had no records indicating occupational exposure to OCPs. Seventeen OCPs were analyzed in this study. The results showed that methoxychlor was dominant, accounted for 13.4% of total OCPs with a mean concentration of 167.9 ± 33.9 ng/g lipid weight (lw), followed by heptachlor-epoxide, hexachlorocyclohexanes, endrin and DDT. The concentrations of OCPs in the follicular fluid samples in the present study were moderate in comparison with those reported from developed or industrialized countries. All these pollutants can accumulate in different tissues of human body through diet, drinking water and respiration. No correlation between patient age and OCP concentrations was observed in this study.