Quantitative study of germinal center area in normal and diseased tonsils using image analysis
Quantitative study of germinal center area in normal and diseased tonsils using image analysis
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DOI：
10.1177/000348949910800414
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发表时间：
1999-04-01
影响因子：
1.4
通讯作者：
Brodsky, L
中科院分区：
文献类型：
--
作者：
Gorfien, JL;Hard, R;Brodsky, L
本研究的目的是利用图像分析，以一致和无偏的方式测量次级毛囊的生发中心面积。扁桃体标本取自有扁桃体炎复发和/或特发性扁桃体肥大临床证据的儿童。正常对照活检标本来自没有耳、鼻或喉咙感染病史的儿童。结果显示，与正常对照组相比，肥大扁桃体的生发中心面积显著增加(p<0.05)。
The aim of this study was to measure the germinal center area of secondary follicles in a consistent and unbiased manner using image analysis. Tonsil specimens were obtained from children with clinical evidence of recurrent tonsillitis and/or idiopathic tonsillar hypertrophy. Normal control biopsy specimens were obtained from children with no history of ear, nose, or throat infections. The results show a significant increase in the germinal center area in tonsils exhibiting hypertrophy when compared to normal controls (p