Mannitol opening of the blood-brain barrier:: regional variation in the permeability of sucrose, but not 86Rb+ or albumin
Mannitol opening of the blood-brain barrier:: regional variation in the permeability of sucrose, but not 86Rb+ or albumin
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DOI：
10.1016/j.brainres.2004.04.034
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发表时间：
2004-07-16
期刊：
影响因子：
2.9
通讯作者：
Davis, TP
中科院分区：
文献类型：
--
作者：
Brown, RC;Egleton, RD;Davis, TP
在临床上，输注高酸性溶液用于增强恶性脑肿瘤或转移患者的血脑屏障（BBB）的化疗药物渗透。我们使用大鼠原位灌注模型检测了高渗性血脑屏障破坏对三种化合物（R-86（+），K+渗透性和转运的标志物，[C-14]蔗糖和伊文思蓝白蛋白）脑渗透性的影响。Rb-86（+）和[C-14]蔗糖在用1.6 M甘露醇破坏BBB后20分钟增加了通透性。伊文思蓝白蛋白渗透性无变化。甘露醇诱导的血脑屏障破坏后，只有[C-14]蔗糖的渗透性表现出区域性变化，皮质和中脑的蔗糖渗透性高于小脑或脑干。这些数据表明，9高渗性破坏疗法与化学治疗剂（与蔗糖分子量相似）联合使用的临床疗效可能受到脑内肿瘤位置的影响。(C)2004 Elsevier B. V.保留所有权利。
Clinically, infusion of hyperosinolar solutions is used to enhance chemotherapeutic drug penetration of the blood-brain barrier (BBB) in patients with malignant brain tumors or metastases. We examined the effect of hyperosmolar BBB disruption on brain permeability of three compounds, R-86(+), a marker for K+ permeability and transport, [C-14] sucrose and Evans blue albumin, using a rat in situ perfusion model. Rb-86(+) and [C-14] sucrose had increased permeability 20 min after BBB disruption with 1.6 M mannitol. There was no change in Evans blue albumin permeability. Only [C-14] sucrose showed regional variation in permeability after mannitol-induced BBB disruption, with the cortex and midbrain having higher sucrose permeability then either the cerebellum or brainstem. These data suggest that the clinical efficacy of 9 hyperosmolar disruption therapy in conjunction with chemotherapeutic agents, of a similar molecular weight to sucrose, may be affected by the location of the tumor within the brain. (C) 2004 Elsevier B.V. All rights reserved.