Inhibition of Intimal Proliferation of Rabbit Aorta by Ticlopidine
Inhibition of Intimal Proliferation of Rabbit Aorta by Ticlopidine
复制标题
噻氯匹定对兔主动脉内膜增殖的抑制作用
DOI：
10.1055/s-0039-1687404
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发表时间：
1979
影响因子：
6.7
通讯作者：
P. L. Walton
中科院分区：
文献类型：
--
作者：
A. Reece;P. L. Walton
血小板释放的生长因子可刺激受损内皮附近动脉内膜中平滑肌细胞的增殖。我们研究了两种血小板功能抑制剂噻氯匹定和Sulphinsultzone对兔腹主动脉内膜增生的影响。手术后每隔一段时间取出主动脉，固定，切片，并使用图像分析仪（Quantlmet 720）测量内膜增殖的程度。对照组和噻氯匹定组内膜生长弧a分别为42.4± 2.8，22.3 ±1.2和50.9± 2.0，33.9±2.0。因此，用噻氯匹定（50 mg/kg/天P.O.）在这些动物中，当Sulphinazone（50 mg/kg/天P.O.）没有效果。用噻氯匹定治疗期间ADP诱导的血小板聚集减少（约30%），但用Sulphinsulzone治疗期间没有减少。这些结果表明，噻氯匹定治疗限制内皮细胞损伤后兔的内膜增殖，并可能在限制这一过程中的人的价值。
Proliferation of smooth muscle cells in the intima of arteries at sites adjacent to damaged endothelium may be stimulated by growth factors released from platelets. We have studied the effect of treatment with two inhibitors of platelet function, Ticlopidine and Sulphlnpyrazone, on the rate and extent of intimal proliferation In rabbit abdominal aorta following endarterectomy using a balloon catheter. Aortas were removed at Intervals after surgery, fixed, sectioned and the extent of intimal proliferation was measured using an Image analyser (Quantlmet 720). The arc a of Intimal growth as a percentage of total area of aorta was 42.4±2.8,22.3±1.2 and 50.9±2.0, 33.9±2.0 in control and Ticlopidine treated animals 30 and 60 days after endarterectomy, respectively. Thus treatment with Ticlopidine (50mg/kg/day P. O.) produced a highly significant (p<.001) reduction In the extent of intimai growth In these animals (c 50%), where as Sulphlnpyrazone (50mg/kg/day P. O.) had no effect. ADP Induced platelet aggregation was reduced (c 30%) during the treatment with Ticlopidine but not during treatment with Sulphlnpyrazone. These findings indicate that Ticlopidine treatment limits intimai proliferation In rabbits following endothelial cell Injury and may be of value in limiting this process In man.