BEHAVIORAL DESPAIR IN RATS - NEW MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS
BEHAVIORAL DESPAIR IN RATS - NEW MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS
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DOI：
10.1016/0014-2999(78)90118-8
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发表时间：
1978-01-01
影响因子：
5
通讯作者：
JALFRE, M
中科院分区：
文献类型：
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作者：
PORSOLT, RD;ANTON, G;JALFRE, M
当大鼠被迫在无法逃脱的圆柱体中游泳时，在最初的剧烈活动期后，将采取易于识别的特征性不动姿势。各种临床有效的抗抑郁药物的剂量，否则会减少在一个开放领域的自发运动活动减少不动。因此，抗抑郁药可以与精神兴奋剂区分开来，后者在增加一般活动的剂量下减少不动性。抗癫痫化合物并不影响不动性，而主要的镇静剂却增强了不动性，电休克、REM（快速眼动）睡眠剥夺和丰富的环境也会降低不动性。不动反映了大鼠情绪低落的状态，这种状态对抗抑郁治疗选择性敏感。非典型抗抑郁药物如伊吲哚和米安色林的阳性结果表明，该方法可能能够发现迄今为止经典药理学测试无法检测到的新的抗抑郁药物。
Rats, when forced to swim in a cylinder from which they cannot escape, will, after an initial period of vigorous activity, adopt a characteristic immobile posture which can be readily identified. Immobility was reduced by various clinically effective antidepressant drugs at doses which otherwise decreased spontaneous motor activity in an open field. Antidepressants could thus be distinguished from psychostimulants which decreased immobility at doses which increased general activity. Anxiolytic compounds did not affect immobility whereas major tranquilizers enhanced it. Immobility was also reduced by electroconvulsive shock, REM [rapid eye movement] sleep deprivation and enrichment of the environment. Immobility reflected a state of lowered mood in the rat which was selectively sensitive to antidepressant treatments. Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggested that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.