The effect of an antibacterial monomer on the antibacterial activity and mechanical properties of a pit-and-fissure sealant
The effect of an antibacterial monomer on the antibacterial activity and mechanical properties of a pit-and-fissure sealant
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抗菌单体对窝沟封闭剂抗菌活性及力学性能的影响
DOI：
10.14219/jada.archive.2011.0062
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发表时间：
2011-02-01
影响因子：
3.9
通讯作者：
Chen, Jihua
中科院分区：
文献类型：
--
作者：
Li, Feng;Li, Fang;Chen, Jihua
背景作者将抗菌单体甲基丙烯酰氧基乙基十六烷基二甲基氯化铵（DMAE-CB）掺入商业窝沟封闭剂中，以评价单体的抗菌活性和机械性能。作者将1重量%的DMAE-CB掺入到市售密封剂（Helioseal，Ivodar Vivadent，沙安，Lichelian）中。不含DMAE-CB的相同密封剂Helioseal用作阴性对照。作者使用含有氟化物释放树脂的Helioseal F（Ivoclar Vivadent）作为阳性对照。他们分别通过薄膜接触试验和吸光度测量确定固化密封剂及其洗脱液对变形链球菌生长的影响。他们测量并比较了表面接触角、转化度、显微硬度和微渗漏。作者发现，与阴性对照封闭剂相比，含DMAE-CB的固化封闭剂对S.而这些封闭剂的洗脱液均未显示出任何可检测的抗菌活性。阳性对照也未显示出可检测的杀菌活性。DMAE-CB组与阴性对照组之间的接触角、转化度、显微硬度和微渗漏均无显著性差异（P > 0.05）。DMAE-CB的加入可以通过影响S.变异人掺入少量的单体DMAE-CB显示对接触角，转化度，硬度和微渗漏的母体材料没有影响。临床意义。结果提供了关于具有抗菌活性的密封剂的潜在临床性能的推断。
Background. The authors incorporated an antibacterial monomer, methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), into a commercial pit-and-fissure sealant to evaluate the monomer's antibacterial activity and mechanical properties.Methods. The authors incorporated DMAE-CB at 1 percent by weight into a commercially available sealant (Helioseal, Ivodar Vivadent, Schaan, Lichtenstein). The same sealant, Helioseal, without DMAE-CB served as a negative control. The authors used Helioseal F (Ivoclar Vivadent), containing a fluoride-releasing resin, as a positive control. They determined effects of the cured sealants and their eluents on the growth of Streptococcus mutans by means of a film contact test and absorbance measurement, respectively. They measured and compared surface contact angle, degree of conversion, microhardness and microleakage.Results. The authors found that in comparison with the negative control sealant, the cured sealant containing DMAE-CB had an inhibitory effect on the growth of S. mutans (P < .05), whereas the eluents of neither of these sealants showed any detectable antibacterial activity. The positive control also showed no detectable bactericidal activity. Moreover, there were no significant differences in the contact angle, degree of conversion, microhardness and microleakage between the DMAE-CB group and the negative control group (P > .05).Conclusions. The incorporation of DMAE-CB can provide sealant with contact antibacterial activity after polymerization by influencing the growth of S. mutans. The incorporation of small amounts of the monomer DMAE-CB showed no influence on the contact angle, degree of conversion, hardness and microleakage of the parental material.Clinical Implications. The results provided inference concerning the potential clinical performance of the sealant with antibacterial activity.