Rapid effects of estrogen or progesterone on the amphetamine-induced increase in striatal dopamine are enhanced by estrogen priming: A microdialysis study
Rapid effects of estrogen or progesterone on the amphetamine-induced increase in striatal dopamine are enhanced by estrogen priming: A microdialysis study
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DOI：
10.1016/s0091-3057(99)00091-x
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发表时间：
1999-09-01
影响因子：
3.6
通讯作者：
Rudick, CN
中科院分区：
文献类型：
--
作者：
Becker, JB;Rudick, CN
安非他明刺激的行为和纹状体多巴胺（DA）的释放有动情周期依赖的差异，完整的雌性大鼠表现出更大的行为反应，安非他明在发情周期的其他日子。以下卵巢切除安非他明诱导的行为减弱，是纹状体DA反应安非他明在体外。重复雌激素治疗卵巢切除大鼠恢复这些反应的水平，可与发情期的女性。此外，30分钟后，一个单一的治疗与生理剂量的雌激素有增强安非他明诱导的行为和增加安非他明诱导的纹状体DA检测在微透析。本实验旨在确定雌二醇的急性效应和重复暴露于雌激素的效应是否在功能上相关。我们在这里报告，先前的治疗与雌激素（5 μ g苯甲酸雌二醇每日治疗三次）的结果在一个显着增强急性雌激素（5 μ g苯甲酸雌二醇）或孕酮（500 μ g）对安非他明诱导的纹状体DA释放和刻板行为的影响。在安非他明前30分钟用雌激素或孕酮处理的雌激素引发动物中，峰值反应和反应持续时间均大于所有其他组。无论是先前的治疗与雌激素（最后一剂24小时前）或单次急性注射雌激素的结果在增强的峰值响应安非他明，安非他明诱导的纹状体DA释放的持续时间没有影响。在未用雌激素致敏的动物中用孕酮处理与用油媒剂处理没有差异。这些结果表明，既有急性的，也有长期的。雌激素对纹状体的影响，是生殖周期中刺激DA释放和安非他明诱导行为的动态变化的基础。(C)1999 Elsevier Science Inc.
There are estrous cycle-dependent differences in amphetamine stimulated behaviors and striatal dopamine (DA) release; intact female rats exhibit a greater behavioral response to amphetamine on estrus than on other days of the cycle. Following ovariectomy amphetamine-induced behavior is attenuated, as is the striatal DA response to amphetamine in vitro. Repeated estrogen treatment in ovariectomized rats reinstates both of these responses to a level comparable to estrous females. In addition, 30 min after a single treatment with a physiological dose of estrogen there is enhanced amphetamine-induced behavior and increased amphetamine-induced striatal DA detected during microdialysis. This experiment was conducted to determine whether the acute effect of estradiol and the effect of repeated exposure to estrogen are functionally related. We report here that prior treatment with estrogen (three daily treatments of 5 mu g estradiol benzoate) results in a significant enhancement of the effect of acute estrogen (5 mu g estradiol benzoate) or progesterone (500 mu g) on amphetamine-induced striatal DA release and stereotyped behaviors. Both the peak response and the duration of the response are greater in estrogen-primed animals treated with estrogen or progesterone 30 min prior to amphetamine, than in all other groups. Either prior treatment with estrogen (last dose 24 h before) or a single acute injection of estrogen result in an enhanced peak response to amphetamine, with no effect on the duration of amphetamine-induced striatal DA release. Treatment with progesterone in animals not primed with estrogen was not different from treatment with oil vehicle. These results demonstrate that there are both acute and long-term. effects of estrogen on the striatum that underlie the dynamic changes in stimulated DA release and amphetamine-induced behaviors during the reproductive cycle. (C) 1999 Elsevier Science Inc.