Resting-State Functional and Structural Connectivity Within an Insula-Amygdala Route Specifically Index State and Trait Anxiety
Resting-State Functional and Structural Connectivity Within an Insula-Amygdala Route Specifically Index State and Trait Anxiety
复制标题
DOI：
10.1016/j.biopsych.2012.06.003
复制
发表时间：
2013-01-01
影响因子：
10.6
通讯作者：
Jaencke, Lutz
中科院分区：
文献类型：
--
作者：
Baur, Volker;Haenggi, Juergen;Jaencke, Lutz
背景资料：在一般的情绪刺激过程中，特别是在与焦虑相关的情境中，经常报告杏仁核和杏仁核的联合活动。然而，在这个框架中，杏仁核和杏仁核之间的直接联系迄今为止很少受到关注。研究是否在焦虑的个体间差异反映在岛杏仁核连接的变化是一种方法，以推动了解网络相关方面的基础anxious behavior.Methods：调查功能和结构的连接，我们采用静息态功能磁共振成像和扩散张量成像在一组32名健康受试者。具体措施之间的子区域的大脑皮层和杏仁核的连接与受试者的焦虑水平。结果：休息状态之间的前额叶和基底外侧杏仁核的功能连接是密切相关的状态焦虑，解释40%的行为变异跨科目。这是证实了应用纤维束成像，产生的特质焦虑和轴向扩散率之间的关系，前额叶和基底外侧amygdala.Conclusions之间的直接通路：我们的研究结果表明，前额叶和基底外侧杏仁核构成网络的一部分，是显着的焦虑。在这条路线中，状态和特质行为的影响似乎是特别与动态功能和静态结构神经方面，分别。胰岛-杏仁核静息状态功能连接可以以简单直接的方式进行评估，并且具有很高的潜力作为焦虑的生物标志物。
Background: Conjoint activity of the insula and amygdala has frequently been reported during emotional stimulation in general and in anxiety-related contexts in particular. However, direct connectivity between the insula and amygdala in this framework has received little attention so far. Studying whether inter-individual differences in anxiety reflect variation in insula-amygdala connectivity is a way to push forward the understanding of network-related aspects underlying anxious behavior.Methods: To investigate functional and structural connectivity, we applied resting-state functional magnetic resonance imaging and diffusion tensor imaging in a group of 32 healthy subjects. Specific measures of connectivity between subregions of the insula and amygdala were related to subjects' anxiety levels.Results: Resting-state functional connectivity between the anterior insula and the basolateral amygdala was strongly related to state anxiety, explaining 40% of behavioral variance across subjects. This was substantiated by applying tractography, yielding a relationship between trait anxiety and axial diffusivity for a direct pathway between anterior insula and basolateral amygdala.Conclusions: Our results indicate that anterior insula and basolateral amygdala constitute a network part that is prominently linked to anxiety. Within this route, state and trait behavioral impacts seem to be specifically linked to dynamic functional and more static structural neural aspects, respectively. Insula-amygdala resting-state functional connectivity can be assessed in an easy and straightforward way and has high potential to serve as a biomarker for anxiety.