AGE-RELATED DECREASES IN INSULIN-LIKE GROWTH-FACTOR-I AND TRANSFORMING GROWTH-FACTOR-BETA IN FEMORAL CORTICAL BONE FROM BOTH MEN AND WOMEN - IMPLICATIONS FOR BONE LOSS WITH AGING
AGE-RELATED DECREASES IN INSULIN-LIKE GROWTH-FACTOR-I AND TRANSFORMING GROWTH-FACTOR-BETA IN FEMORAL CORTICAL BONE FROM BOTH MEN AND WOMEN - IMPLICATIONS FOR BONE LOSS WITH AGING
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DOI：
10.1210/jc.78.5.1011
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发表时间：
1994-05-01
影响因子：
5.8
通讯作者：
FARLEY, JR
中科院分区：
文献类型：
--
作者：
NICOLAS, V;PREWETT, A;FARLEY, JR
We determined the skeletal content of insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF beta) in human bone as a function of age, using 66 samples of femoral cortical bone obtained from 46 men and 20 women between the ages of 20-64 yr. We found a linear decline in the skeletal content of IGF-I (nanograms per mg protein) with donor age (r = -0.43; P < 0.001) in the total population. The skeletal content of TGF beta also decreased with age (i.e. 1/TGF beta us. age; r = 0.28; P < 0.02) for the total population. We did not observe any difference in the skeletal growth factor content between male and female donors. IGF-I content, when analyzed by decade divisions of age, showed a reduction between the 20- to 29-yr-old and the 50- to 59yr-old subjects (P < 0.02). The loss rate of IGF-I was 1.56 ng/mg protein yr, corresponding to a net loss of 60% of skeletal IGF-I between the ages of 20-60 yr. The loss rate of TGF beta was 0.03 ng/mg protein yr, corresponding to a net loss of 25% of the skeletal TGF beta between the ages of 20-60 yr.
