The Long Neglected Cycloidal Mass Analyzer
The Long Neglected Cycloidal Mass Analyzer
复制标题
长期被忽视的摆线质量分析仪
DOI：
10.1021/acs.analchem.1c02001
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发表时间：
2021
影响因子：
7.4
通讯作者：
Sartorelli, Maria L.
中科院分区：
文献类型：
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作者：
Piacentino, Elettra L.;Serpa, Rafael Bento;Horvath, Kathleen L.;Vyas, Raul;Aloui, Tanouir;Parker, Charles B.;Carlson, James B.;Keogh, Justin;Sperline, Roger P.;Sartorelli, Maria L.
1938 年，Walker Bleakney 和 John A. Hipple 首次将摆线质量分析器描述为唯一能够实现“完美”离子聚焦的质量分析器配置。为什么它们的几何形状多年来一直被忽视？它如何在现代化学分析领域赢得受人尊敬的地位？本视角探讨了摆线质量分析器的特性，并指出缺乏合适的离子阵列检测器是摆线质量分析器未广泛使用的一个重要原因。最近开发的电容式互阻抗放大器阵列检测器可以实现使用摆线质量分析器的多种技术，包括空间编码孔径和具有“虚拟狭缝”的单粒子质量分析，帮助摆线质量分析器在化学分析中赢得了良好的地位。
In 1938, Walker Bleakney and John A. Hipple first described the cycloidal mass analyzer as the only mass analyzer configuration capable of “perfect” ion focusing. Why has their geometry been largely neglected for many years and how might it earn a respectable place in the world of modern chemical analysis? This Perspective explores the properties of the cycloidal mass analyzer and identifies the lack of suitable ion array detectors as a significant reason why cycloidal mass analyzers are not widely used. The recent development of capacitive transimpedance amplifier array detectors can enable several techniques using cycloidal mass analyzers including spatially coded apertures and single particle mass analysis with a “virtual-slit”, helping the cycloidal mass analyzer earn a respectable place in chemical analysis.