Region-specific glutamate changes in patients with unipolar depression
Region-specific glutamate changes in patients with unipolar depression
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DOI：
10.1016/j.jpsychires.2012.04.018
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发表时间：
2012-08-01
影响因子：
4.8
通讯作者：
Bajbouj, Malek
中科院分区：
文献类型：
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作者：
Grimm, Simone;Luborzewski, Alexander;Bajbouj, Malek
本研究旨在研究单相抑郁症患者中扣带回皮质（MCC）与左背外侧前额叶皮质（DLPFC）的谷氨酸浓度。我们假设谷氨酸水平与DLPFC中的水平不变和MCC中的水平异常变化以及抗抑郁药物治疗的差异效应分离。采用3T磁共振波谱法测定14名抑郁症患者和匹配的健康志愿者DLPFC和MCC的谷氨酸。抗抑郁药治疗4周后进行随访测量。主要发现是一个区域特异性模式的谷氨酸浓度增加MCC谷氨酸浓度和DLPFC谷氨酸浓度在单相抑郁症患者相比，健康对照组没有显着差异。在DLPFC和MCC中，抗抑郁药物治疗的应答和无应答分别由基线时的高谷氨酸预测。此外，治疗应答者在成功的抗抑郁药治疗后显示DLPFC谷氨酸水平进一步增加。研究结果表明，DLPFC和MCC中特定区域的谷氨酸浓度改变，分别预测抗抑郁药物治疗的反应和无反应。这些发现可能作为未来研究的起点，其中应研究这种代谢物模式对治疗反应预测的价值。(C)2012爱思唯尔有限公司保留所有权利。
The present study aimed to investigate glutamate concentrations in patients with unipolar depression in the midcingulate cortex (MCC) as compared to the left dorsolateral prefrontal cortex (DLPFC). We hypothesized a dissociation of glutamate levels with unchanged levels in DLPFC and abnormally changed levels in MCC as well as differential effects of antidepressant pharmacotherapy. Glutamate was determined using magnetic resonance spectroscopy at 3 T in DLPFC and MCC in fourteen depressed patients and matched healthy volunteers. A follow-up measurement was performed after 4 weeks of antidepressant treatment. The main finding is a region-specific pattern of glutamate concentrations with increased MCC glutamate concentrations and no significant differences in DLPFC glutamate concentrations in unipolar depressive patients compared to healthy controls. Response and non-response to antidepressant pharmacotherapy were predicted by high glutamate at baseline in DLPFC and MCC, respectively. In addition, treatment responders showed a further increase in DLPFC glutamate levels after successful antidepressant treatment. Findings indicate altered region-specific glutamate concentrations in DLPFC and MCC that are predictive of response and non-response, respectively, to antidepressant pharmacotherapy. These findings might serve as a starting point for future studies in which the value of this metabolite pattern for treatment response prediction should be investigated. (C) 2012 Elsevier Ltd. All rights reserved.