Guaiane-Type Sesquiterpenoids from Alismatis Rhizoma and Their Anti-inflammatory Activity
Guaiane-Type Sesquiterpenoids from Alismatis Rhizoma and Their Anti-inflammatory Activity
复制标题
DOI：
10.1248/cpb.c16-00798
复制
发表时间：
2017-04-01
影响因子：
1.7
通讯作者：
Zhao, Qin-Shi
中科院分区：
文献类型：
--
作者：
Li, Hong-Mei;Fan, Min;Zhao, Qin-Shi
从泽泻（Minna orientale的干燥根茎）中分离出12种愈创木烷型倍半萜类化合物，包括4种新化合物：10 - O - 甲基东方醇A（1）、10 - O - 乙基泽泻醇氧化物（2）、3β,4β - 环氧金粟兰醇（3）、东方醇G（4），以及一种新的降倍半萜类化合物东方醇H（5）。根据光谱数据阐明了新化合物的结构。此外，测试了所有化合物对脂多糖（LPS）诱导的RAW264.7细胞中一氧化氮（NO）产生的抑制作用。
Twelve guaiane-type sesquiterpenoids, including four new ones, 10-O-methyl-orientalol A (1), 10-O-ethyl-alismoxide (2), 3 beta,4 beta-expoxy-chrysothol (3), orientalol G (4), and a new norsesquiterpenoid, orientalol H (5), were isolated from Chinese Alismatis Rhizoma, the dried rhizome of Minna orientale. The structures of new compounds were elucidated on the basis of spectroscopic data. Moreover, the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells of all compounds was tested.