Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization
Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization
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DOI：
10.1152/ajpregu.00220.2015
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发表时间：
2016-04-01
影响因子：
2.8
通讯作者：
Baskin, Denis G.
中科院分区：
文献类型：
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作者：
Blevins, James E.;Thompson, Benjamin W.;Baskin, Denis G.
基于大量的短期管理研究，越来越多的证据表明，中央催产素是重要的能量平衡的调节。目前工作的目标是确定是否长期第三脑室（3V）催产素输注到中枢神经系统（CNS）是有效的肥胖预防和/或治疗大鼠模型。我们发现，慢性3V催产素输注之间的21和26天的渗透微型泵都减少了体重增加与高脂饮食（HFD）诱导的肥胖症的进展，并引起持续减少脂肪量，而没有减少瘦体重与建立饮食诱导的肥胖症大鼠。我们进一步证明，这些慢性催产素效应是由于1）尽管体重持续下降，但能量消耗仍维持在干预前水平，2）呼吸商降低，与脂肪氧化增加一致，3）对胆囊收缩素-8的饱腹感反应增强以及相关的膳食量减少。这些减肥效果持续约10天后终止3V催产素管理和发生独立的蔗糖是否被添加到HFD。我们得出结论，长期3V管理
Based largely on a number of short-term administration studies, growing evidence suggests that central oxytocin is important in the regulation of energy balance. The goal of the current work is to determine whether long-term third ventricular (3V) infusion of oxytocin into the central nervous system (CNS) is effective for obesity prevention and/or treatment in rat models. We found that chronic 3V oxytocin infusion between 21 and 26 days by osmotic minipumps both reduced weight gain associated with the progression of high-fat diet (HFD)-induced obesity and elicited a sustained reduction of fat mass with no decrease of lean mass in rats with established diet-induced obesity. We further demonstrated that these chronic oxytocin effects result from 1) maintenance of energy expenditure at preintervention levels despite ongoing weight loss, 2) a reduction in respiratory quotient, consistent with increased fat oxidation, and 3) an enhanced satiety response to cholecystokinin-8 and associated decrease of meal size. These weight-reducing effects persisted for approximately 10 days after termination of 3V oxytocin administration and occurred independently of whether sucrose was added to the HFD. We conclude that long-term 3V administration