Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin
Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin
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DOI：
10.1046/j.1523-1747.1999.00760.x
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发表时间：
1999-11-01
影响因子：
6.5
通讯作者：
Majzoub, JA
中科院分区：
文献类型：
--
作者：
Arbiser, JL;Karalis, K;Majzoub, JA
下丘脑神经肽促肾上腺皮质激素释放激素是下丘脑内分泌垂体-肾上腺轴的主要调节因子。促肾上腺皮质激素释放激素也在许多外周部位表达，其功能尚不清楚。它也由多种肿瘤分泌，可能与恶性行为有关。为了提供有关促肾上腺皮质激素释放激素在外周部位和肿瘤中的功能的信息，我们询问促肾上腺皮质激素释放激素是否具有血管生成特性。在体外，我们发现人促肾上腺皮质激素释放激素通过促肾上腺皮质激素释放激素受体依赖性机制特异性地刺激内皮趋化性。在体内，皮下接种裸鼠与人上皮肿瘤细胞工程分泌促肾上腺皮质激素释放激素与显着增强血管生成（2.3倍以上的控制）和肿瘤生长（5倍以上的控制）。因此，外周促肾上腺皮质激素释放激素可以增强局部血管生成，这可能为其在神经系统外的功能提供线索。
The hypothalamic neuropeptide corticotropin-releasing hormone is the major hypothalamic regulator of the endocrine pituitary-adrenal axis. Corticotropin-releasing hormone is also expressed in many peripheral sites, where its functions are unclear. It is also secreted by diverse neoplasms, where it may be associated with malignant behavior. To provide information regarding the function of corticotropin-releasing hormone in peripheral sites and in tumors, we asked whether corticotropin-releasing hormone has angiogenic properties, In vitro, we found that human corticotropin-releasing hormone specifically stimulates endothelial chemotaxis via a corticotropin-releasing hormone receptor-dependent mechanism. In vivo, subcutaneous inoculation of nude mice with human epithelial tumor cells engineered to secrete corticotropin-releasing hormone was associated with significantly enhanced angiogenesis (2.3-fold over control) and tumor growth (5-fold over control). Peripheral corticotropin-releasing hormone may thus enhance local angiogenesis, which may provide clues to its function outside of the nervous system.