Exploring the association between a cholecystokinin promoter polymorphism (rs1799923) and posttraumatic stress disorder in combat veterans
Exploring the association between a cholecystokinin promoter polymorphism (rs1799923) and posttraumatic stress disorder in combat veterans
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DOI：
10.1016/j.janxdis.2015.09.009
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发表时间：
2015-12-01
影响因子：
10.3
通讯作者：
Wang, Zhewu
中科院分区：
文献类型：
--
作者：
Badour, Christal L.;Hirsch, R. Louis;Wang, Zhewu
背景：胆囊收缩素（CCK）是一种神经肽，与理解恐惧的获得和消除有关。CCK在焦虑中的研究主要集中在理解惊恐发作和惊恐障碍。新出现的数据表明，CCK可能在理解创伤后应激障碍（PTSD）的发展和维持方面也有希望。方法：本研究在457名参战老兵的样本中检测了CCK基因启动子区域（C > T; rs1799923）的单核苷酸多态性是否与PTSD患病率增加以及PTSD症状的严重程度有关。结果：结果表明，携带杂合或纯合T等位基因的受试者与携带CC基因型的受试者相比，PTSD患病率更高（or =2.17; 95% CI[1.37-3.43]）。局限性：相对较小的样本量妨碍了对种族/民族差异的检查。由于缺乏对共病焦虑精神病理的系统评估，研究结果也受到限制。结论：这些数据为CCK基因rs1799923多态性与PTSD之间的关联提供了初步证据。需要进一步的研究来更好地理解这种关系的本质。Elsevier Ltd.出版。
Background: Cholecystokinin (CCK) is a neuropeptide that has been implicated in understanding the acquisition and extinction of fear. Research on CCK in anxiety has primarily focused on understanding panic attacks and panic disorder. Emerging data suggests that CCK may also hold promise in understanding the development and maintenance of posttraumatic stress disorder (PTSD).Method: The present study examined whether a single nucleotide polymorphism in the promoter region of the CCK gene (C > T; rs1799923) was associated with an increased prevalence of PTSD as well as with severity of PTSD symptoms among a sample of 457 combat veterans.Results: Results demonstrated that participants with either the heterozygous or homozygous T allele had an increased prevalence of PTSD relative to participants with the CC genotype (OR=2.17; 95% CI [1.37-3.43]).Limitations: The relatively small sample size precluded examination of racial/ethnic differences. Findings were also limited by the absence of a systematic assessment of comorbid anxiety psychopathology.Conclusions: These data offer preliminary evidence supporting an association between the rs1799923 polymorphism in the CCK gene and PTSD. Additional research is needed to better understand the nature of this relationship. Published by Elsevier Ltd.