Plasma cortisol and aggression in boys with ADHD.
Plasma cortisol and aggression in boys with ADHD.
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患有多动症的男孩的血浆皮质醇和攻击性。
DOI：
10.1097/00004583-199705000-00010
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Gabriel,S
中科院分区：
文献类型：
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作者：
Schulz,KP;Halperin,JM;Newcorn,JH;Sharma,V;Gabriel,S
几项研究的结果表明，皮质醇分泌和攻击行为之间存在反比关系。本研究检测了患有注意力缺陷多动障碍（ADHD）的攻击性和非攻击性男孩的基础血浆皮质醇水平。方法受试者为23名攻击性ADHD男孩和27名非攻击性ADHD男孩，年龄7至11岁。在低单胺饮食3天和禁食过夜后，将留置导管插入前臂静脉。血浆皮质醇水平的样本在插入导管后105和115分钟获得，控制体重的MANTSA单因素协方差分析（ANCOVA）显示，攻击性和非攻击性男孩之间的血浆皮质醇没有显着差异。此外，当儿童根据是否存在DSM-III-R诊断的行为障碍而被交替划分时，一个-ANCOVA再次显示皮质醇水平无显著差异。结论：ADHD男孩皮质醇分泌与攻击行为之间的假设负相关关系未被发现。这些发现与大量文献一致，表明ADHD的生物学基础攻击性是复杂的，并且在这个时候识别攻击性行为的生物实验室标记物不是临床上有用的策略。J. Am. Acad.儿童青少年精神病学，1997，36（5）：605-609.
OBJECTIVEThe results of several studies suggest an inverse relationship between cortisol secretion and aggressive behavior. This study examined basal plasma cortisol levels in aggressive and nonaggressive boys with attention-deficit hyperactivity disorder (ADHD).METHODThe subjects were 23 aggressive and 27 nonaggressive boys with ADHD, aged 7 to 11 years. After 3 days of a low monoamine diet and an overnight fast, an indwelling catheter was inserted into a forearm vein. Samples for plasma cortisol levels were obtained 105 and 115 minutes after insertion of the catheter.RESULTSA one-way analysis of covariance (ANCOVA) controlling for body mass revealed no significant difference in plasma cortisol between the aggressive and nonaggressive boys. Furthermore, when the children were alternatively divided on the basis of the presence or absence of a DSM-III-R diagnosis of conduct disorder, a one-way ANCOVA again revealed no significant difference in cortisol levels.CONCLUSIONSThe hypothesized inverse relationship between cortisol secretion and aggressive behavior in boys with ADHD was not found. These findings are consistent with a large body of literature indicating that the biological substrate of aggression is complex and that the identification of biological laboratory markers of aggressive behavior is not a clinically useful strategy at this time. J. Am. Acad. Child Adolesc. Psychiatry, 1997, 36(5):605–609.