Sirtuins and Cancer: New Insights and Cell Signaling
Sirtuins and Cancer: New Insights and Cell Signaling
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DOI：
10.3109/07357907.2013.853076
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发表时间：
2013-12-01
影响因子：
2.4
通讯作者：
Sousa Santos, Sergio Henrique
中科院分区：
文献类型：
--
作者：
Macedo de Oliveira, Marcos Vinicius;Oliveira Andrade, Joao Marcus;Sousa Santos, Sergio Henrique
Sirtuins参与细胞周期的控制和基因转录的调节。虽然一些sirtuins具有肿瘤抑制作用，但其他sirtuins调节肿瘤代谢。在这个角度来看，本文章是一个审查目前的作用sirtuins的病因学和病理生理学的癌症。Sirtuins显示出成为癌症的有价值的预测和预后标志物的强大潜力，并且适合作为各种肿瘤的治疗靶点。必须鼓励研究能够调节sirtuins活性的新分子。
Sirtuins are involved in the control of the cell cycle and regulation of gene transcription. While some sirtuins have tumor suppressor effects, others regulate tumors metabolism. Within this perspective, the present article is a review of the current role of sirtuins in the etiology and physiopathology of cancer. Sirtuins show strong potential to become a valuable predictive and prognostic marker for cancer and are eligible as therapeutic targets for a variety of tumors. Investigation of new molecules able to modulate sirtuins activity must be encouraged.