A Free-Radical Cascade Methylation/CyClization of N-Arylacrylamides and lsocyanides with Dicumyl Peroxide
A Free-Radical Cascade Methylation/CyClization of N-Arylacrylamides and lsocyanides with Dicumyl Peroxide
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DOI：
10.1021/ol502738a
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发表时间：
2014-11-07
期刊：
影响因子：
5.2
通讯作者：
Liu, Zhong-Quan
中科院分区：
文献类型：
--
作者：
Xu, Zhengbao;Yan, Chaoxian;Liu, Zhong-Quan
以过氧化二氨基作为甲基化试剂，证明了多种n -芳基丙烯酰胺和异氰酸酯的自由基级联甲基化/环化，为各种甲基化n -杂环如吲哚和菲菲啶提供了方便和选择性的途径。
A free-radical cascade methylation/cyclization of a wide range of N-arylacrylamides and isocyanides is demonstrated by using dicumyl peroxide as the methylating reagent, which provides a convenient and selective access to various methylated N-heterocycles such as oxindoles and phenanthridines.