Evolution in a multi-host parasite: Chronobiological circadian rhythm and population genetics of Schistosoma japonicum cercariae indicates contrasting definitive host reservoirs by habitat
Evolution in a multi-host parasite: Chronobiological circadian rhythm and population genetics of Schistosoma japonicum cercariae indicates contrasting definitive host reservoirs by habitat
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DOI：
10.1016/j.ijpara.2009.06.003
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发表时间：
2009-12-01
影响因子：
4
通讯作者：
Webster, Joanne P.
中科院分区：
文献类型：
--
作者：
Lu, Da-Bing;Wang, Tian-Ping;Webster, Joanne P.
日本血吸虫病是一种具有深远医学和兽医学意义的疾病，在许多地区仍然是地方病，并在中国以前控制的地方重新出现。虽然超过40种哺乳动物被怀疑是日本血吸虫的宿主，但它们的相对作用，特别是野生动物，仍有待确定。尾蚴羽化是一种受终末宿主行为影响的可遗传性状，本文对我国两个不同生态区的钉螺进行了3次尾蚴羽化的时间生物学试验，并对尾蚴进行了遗传分析。确定了两种不同的模式，下午晚些时候出现主要发现在丘陵地区，兼容夜间啮齿动物水库，和早期出现在沼泽地内与昼夜牛水库一致。此外，遗传分析指出，具有不同生物学性状的尾蚴之间存在明显的分离。在两个区域之间和两个区域内鉴定的寄生虫的表型和基因型分化可能表明菌株复合体。这种寄生虫的多样性，反过来，可以提供一个解释不同的感染情况下观察到的两个区域之间，因此有重要的应用方面的关键水库的有针对性的控制。(C)2009年澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
Schistosomiasis japonica is a disease of profound medical and veterinary importance which has remained endemic in many regions and has re-emerged where previously controlled in China. Although over 40 mammalian species are suspected as reservoirs for Schistosoma japonicum, their relative roles, particularly wildlife, remain to be ascertained. As cercarial emergence is a heritable trait shaped by the definitive hosts' behaviour, three chronobiological trials of cercarial emergence from field-collected snails from two contrasting ecological regions within China were performed, followed by genetic analyses of the parasites. Two distinct modes were identified, with late afternoon emergence mainly found in the hill region, compatible with a nocturnal rodent reservoir, and early emergence within the marshland consistent with a diurnal cattle reservoir. Furthermore, genetic analyses pointed to a clear separation between cercariae with different biological traits. The phenotypic and genotypic differentiation of the parasites identified here between and within two regions may indicate a strain complex. Such parasite diversity could, in turn, provide an explanation for the different infection scenarios observed between the two regions, and hence have important applied implications in terms of targeted control of key reservoirs. (C) 2009 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.