Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production
Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production
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DOI：
10.1016/j.bbrc.2012.12.121
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发表时间：
2013-02-08
影响因子：
3.1
通讯作者：
Hyun, Chang-Kee
中科院分区：
文献类型：
--
作者：
Kim, Sun-Woo;Park, Kun-Young;Hyun, Chang-Kee
最近，益生菌鼠李糖乳杆菌GG（LGG）已显示出几种有益的效果，包括改善胰岛素敏感性。为了阐明LGG的胰岛素增敏作用的机制，小鼠经口给予LGG 13周，并检查其体重、胰岛素敏感性以及与糖和脂质代谢相关的基因表达。LGG治疗组小鼠体重增加减少，胰岛素敏感性增强，而正常饮食组无变化。肝脏中脂肪酸氧化基因的表达增加，而脂肪酸生成基因的表达减少。骨骼肌中GLUT4 mRNA表达和脂肪组织中脂联素的产生显著增加。这与骨骼肌和脂肪组织中AMPK的活化增加相证实。总之，这些结果表明，LGG治疗通过刺激脂联素分泌和随后的AMPK活化来改善胰岛素敏感性并减少脂质积累。(C)2013 Elsevier Inc. All rights reserved.
Recently, a probiotic Lactobacillus rhamnosus GG (LGG) has shown several beneficial effects, including improved insulin sensitivity. To clarify the mechanism underlying the insulin-sensitizing effect of LGG, mice were orally administrated with LGG for 13 weeks, and their body weight, insulin sensitivity, and expression of genes related to glucose and lipid metabolism were examined. LGG-treated mice showed attenuated weight gain and enhanced insulin sensitivity in high fat diet group, while no change was observed in normal diet-fed group. The expression of fatty acid oxidative genes in the liver was increased and gluconeogenic genes were decreased. GLUT4 mRNA expression in skeletal muscle and adiponectin production in adipose tissue were significantly increased. This was corroborated with the increased activation of AMPK in skeletal muscle and adipose tissue. Taken together, these results indicate that LGG treatment improves insulin sensitivity and reduces lipid accumulation by stimulating adiponectin secretion and consequent activation of AMPK. (C) 2013 Elsevier Inc. All rights reserved.