Tricyclic Antidepressant Analysis by Reversed Phase Liquid Chromato-Graphy Using Phenyl Columns
Tricyclic Antidepressant Analysis by Reversed Phase Liquid Chromato-Graphy Using Phenyl Columns
复制标题
使用苯基柱的反相液相色谱分析三环类抗抑郁药
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
K. Cohen
中科院分区：
文献类型：
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作者：
S. Wong;S. L. McHugh;J. Dolan;K. Cohen
摘要采用两根迷你苯基柱（4.5 × 50 mm），建立了反相液相色谱法分析三环类抗抑郁药（TCA）的新方法。分析分为两个药物组：1。n-去甲基多虑平，多虑平，去甲替林和阿米替林，2。去西帕明和丙咪嗪。样品制备根据已发表的程序（Wong和McCauley， J. Liq. chrnatogr）进行修改。以正己烷/异戊醇（99:1）为有机萃取剂，再用二醇反萃取。磷酸。这两个步骤都是用聚丙烯管进行的，以减少吸附
Abstract Tricyclic antidepressant (TCA) analysis by reversed-phase liquid chromatography was achieved by a novel approach using two mini phenyl columns (4.5 × 50 mm). Analyses were organized into two drug groups: 1. n-desmethyl doxepin, doxepin, nortriptyline and amitriptyline, and 2. desipramine and imipramine. Sample preparation was modified from a published procedure (Wong and McCauley, J. Liq. Chrornatogr., 4, 849 (1981), using n-hexane/isoanyl alcohol (99:1) as the organic extractant, followed by back-extracting with dil. phosphoric acid. Both steps were carried out by using polypropylene tubes to minimize adsorptive
液相色谱法测定八种三环和四环抗抑郁药及其主要活性代谢物。
影响因子：
9.3
作者：
Sutfin,TA;D'Ambrosio,R;Jusko,WJ
通讯作者：
Jusko,WJ