The analgesic effect of electroacupuncture on acute thermal pain perception--a central neural correlate study with fMRI.
The analgesic effect of electroacupuncture on acute thermal pain perception--a central neural correlate study with fMRI.
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DOI：
10.1186/1744-8069-7-45
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发表时间：
2011-06-07
期刊：
影响因子：
3.3
通讯作者：
Leung A
中科院分区：
文献类型：
--
作者：
Shukla S;Torossian A;Duann JR;Leung A
电针（EA）已被用于急性疼痛管理。然而，导致镇痛作用的神经元机制仍然没有很好地定义。当前的研究利用急性疼痛的EA治疗方案和功能性磁共振成像（fMRI）评估了非毒性EA对与有害性热痛（HP）刺激相关的脊髓上区域的强度[最佳EA（OI-EA）与最小EA（MI-EA）]影响行为变化的相关性。受试者接受了五种fMRI扫描模式：一种是热痛（HP），两种是OI-EA和MI-EA，两种是OI-EA和HP，MI-EA和HP。虽然HP导致了已知用于疼痛处理和感知的脊髓上区域的激活（兴奋效应），但EA范式主要导致了大多数这些相应区域的失活（抑制效应）。此外，与MI-EA相比，OI-EA导致更强大的脊髓上镇静作用。因此，OI-EA比MI-EA更有效地抑制HP在与疼痛处理和感知相关的脊髓上区域的兴奋作用。电针强度在调节中枢痛觉中起重要作用。
Electrical acupuncture (EA) has been utilized in acute pain management. However, the neuronal mechanisms that lead to the analgesic effect are still not well defined. The current study assessed the intensity [optimal EA (OI-EA) vs. minimal EA (MI-EA)] effect of non-noxious EA on supraspinal regions related to noxious heat pain (HP) stimulation utilizing an EA treatment protocol for acute pain and functional magnetic resonance imaging (fMRI) with correlation in behavioral changes. Subjects underwent five fMRI scanning paradigms: one with heat pain (HP), two with OI-EA and MI-EA, and two with OI-EA and HP, and MI-EA and HP. While HP resulted in activations (excitatory effect) in supraspinal areas known for pain processing and perception, EA paradigms primarily resulted in deactivations (suppressive effect) in most of these corresponding areas. In addition, OI-EA resulted in a more robust supraspinal sedative effect in comparison to MI-EA. As a result, OI-EA is more effective than MI-EA in suppressing the excitatory effect of HP in supraspinal areas related to both pain processing and perception. Intensities of EA plays an important role in modulating central pain perception.
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影响因子：
7.4
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