During pain-avoidance neurons activated in the macaque anterior cingulate and caudate
During pain-avoidance neurons activated in the macaque anterior cingulate and caudate
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DOI：
10.1016/s0304-3940(00)00894-6
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发表时间：
2000-03-31
影响因子：
2.5
通讯作者：
Mikami, A
中科院分区：
文献类型：
--
作者：
Koyama, T;Kato, K;Mikami, A
前扣带皮层（ACC）或尾状核（CN）的损伤会损害对伤害性躯体刺激的回避行为，因此这两个区域可能在疼痛回避行为中发挥类似的作用。为了验证这一假设，我们记录了单个神经元活动的ACC和CN的猴子，而它正在执行疼痛回避任务。136个ACC中的10个和160个CN神经元中的11个在疼痛回避行为期间选择性地响应。我们发现，在人口分布或反应潜伏期和持续时间的差异不大。我们目前的研究结果是根据以前的病变和解剖研究表明，这两个区域可以作为一个模块在疼痛回避行为。(C)2000由Elsevier Science爱尔兰有限公司出版。保留所有权利。
Lesions in either the anterior cingulate cortex (ACC) or the caudate nucleus (CN) impair avoidance behavior from noxious somatic stimuli, so these two areas may play a similar role in pain-avoidance behavior. To test this hypothesis, we recorded single neuronal activities in the ACC and in the CN of a monkey while it was performing a pain-avoidance task. Ten of 136 ACC and eleven of 160 CN neurons responded selectively during pain-avoidance behavior. We found little difference in the population distribution or in the response latency and duration. Our present findings are in accordance with previous lesion and anatomical studies which suggest that these two regions could function as one module in pain-avoidance behavior. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.