Morbidity associated with sickle cell disease in pregnancy
Morbidity associated with sickle cell disease in pregnancy
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DOI：
10.1016/j.ajog.2008.04.016
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发表时间：
2008-08-01
影响因子：
9.8
通讯作者：
James, Andra H.
中科院分区：
文献类型：
--
作者：
Villers, Margaret S.;Jamison, Margaret G.;James, Andra H.
目的：本研究的目的是确定与妊娠镰状细胞病（SCD）相关的发病率。研究设计：从2000-2003年医疗保健研究和质量机构的医疗保健成本和利用项目中查询所有诊断为SCD的妊娠相关出院患者样本。结果：SCD妇女共分娩17,952例（占总数的0.1%）。有10人死亡（每10万次分娩中有72.4人死亡）。脑静脉血栓形成、肺炎、肾盂肾炎、深静脉血栓形成、输血、产后感染、败血症和全身炎症反应综合征在SCD女性中更为常见。她们更有可能接受剖宫产，经历与妊娠相关的并发症（如妊娠高血压/先兆子痫、子痫、早剥、产前出血、早产和胎儿生长受限），并在分娩时患有心肌病或肺动脉高压。结论：镰状细胞病妇女在妊娠期发病的风险比先前估计的要高。
OBJECTIVE: The purpose of this study was to identify morbidity that is associated with sickle cell disease (SCD) in pregnancy.STUDY DESIGN: The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality for the years 2000-2003 was queried for all pregnancy-related discharges with a diagnosis of SCD.RESULTS: There were 17,952 deliveries (0.1% of the total) to women with SCD. There were 10 deaths (72.4 per 100,000 deliveries). Cerebral vein thrombosis, pneumonia, pyelonephritis, deep venous thrombosis, transfusion, postpartum infection, sepsis, and systemic inflammatory response syndrome were much more common among women with SCD. They were more likely to undergo cesarean delivery, to experience pregnancy-related complications (such as gestational hypertension/preeclampsia, eclampsia, abruption, antepartum bleeding, preterm labor, and fetal growth restriction), and to have cardiomyopathy or pulmonary hypertension at the time of delivery.CONCLUSION: Women with sickle cell disease are at greater risk for morbidity in pregnancy than previously estimated.