Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage
Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage
复制标题
DOI：
10.1113/jp272472
复制
发表时间：
2016-09-15
影响因子：
5.5
通讯作者：
Ugrinowitsch, Carlos
中科院分区：
文献类型：
--
作者：
Damas, Felipe;Phillips, Stuart M.;Ugrinowitsch, Carlos
关键点骨骼肌肥大是阻力训练（RT）的主要结果之一，但在整个训练过程中如何调节它仍然是未知的。我们发现，在RT的第一周（T1）的初始阻力运动（RE）回合后，肌原纤维蛋白合成（MyoPS）的变化大于在RT的第三周（T2）和第十周（T3）的RE后所看到的，在T2和T3的值是相似的。在T1时RE后恢复期间，肌肉损伤（Z带流）最高，T2时较低，T3时最低。当肌肉损伤最高时，整合的MyoPS（T1）也是如此，但两者都与肥大无关;然而，T2和T3的整合MyoPS与肥大相关。我们的结论是，肌肉肥大的结果，积累间歇性增加MyoPS主要后进行性衰减muscle damage. Abstractskeleton肌肉肥大的主要结果之一的阻力训练（RT），但如何调制和调节机制仍然是未知的。为了研究肌肉肥大是如何通过RT调节的，我们使用氧化氘测量了每日整合的肌原纤维蛋白合成（MyoPS），并在RT开始（T1）、3周（T2）和10周（T3）评估了肌肉损伤。10名年轻男性（27（1）岁，平均值（SEM））在T1、T2和T3进行肌肉活检（股外侧肌），以测量抗阻运动前、抗阻运动后24小时和48小时（RE后）的综合MyoPS和肌肉损伤（Z带流和间接参数）。使用T1、T2和T3的活检评估纤维横截面积（fCSA）。仅在T3时观察到fCSA增加（P=0.017）。RE后T1、T2、T3时MyoPS的变化在T1时更大（P
Key points Skeletal muscle hypertrophy is one of the main outcomes from resistance training (RT), but how it is modulated throughout training is still unknown. We show that changes in myofibrillar protein synthesis (MyoPS) after an initial resistance exercise (RE) bout in the first week of RT (T1) were greater than those seen post-RE at the third (T2) and tenth week (T3) of RT, with values being similar at T2 and T3. Muscle damage (Z-band streaming) was the highest during post-RE recovery at T1, lower at T2 and minimal at T3. When muscle damage was the highest, so was the integrated MyoPS (at T1), but neither were related to hypertrophy; however, integrated MyoPS at T2 and T3 were correlated with hypertrophy. We conclude that muscle hypertrophy is the result of accumulated intermittent increases in MyoPS mainly after a progressive attenuation of muscle damage.AbstractSkeletal muscle hypertrophy is one of the main outcomes of resistance training (RT), but how hypertrophy is modulated and the mechanisms regulating it are still unknown. To investigate how muscle hypertrophy is modulated through RT, we measured day-to-day integrated myofibrillar protein synthesis (MyoPS) using deuterium oxide and assessed muscle damage at the beginning (T1), at 3weeks (T2) and at 10weeks of RT (T3). Ten young men (27(1)years, mean (SEM)) had muscle biopsies (vastus lateralis) taken to measure integrated MyoPS and muscle damage (Z-band streaming and indirect parameters) before, and 24h and 48h post resistance exercise (post-RE) at T1, T2 and T3. Fibre cross-sectional area (fCSA) was evaluated using biopsies at T1, T2 and T3. Increases in fCSA were observed only at T3 (P=0.017). Changes in MyoPS post-RE at T1, T2 and T3 were greater at T1 (P