Altered patterns of brain activity during transient sadness in children at familial risk for major depression
Altered patterns of brain activity during transient sadness in children at familial risk for major depression
复制标题
DOI：
10.1016/j.jad.2011.08.010
复制
发表时间：
2011-12-01
影响因子：
6.6
通讯作者：
Booij, Linda
中科院分区：
文献类型：
--
作者：
Levesque, Melissa L.;Beauregard, Mario;Booij, Linda
简介：我们使用功能磁共振成像（fMRI）来研究悲伤的神经相关性，悲伤是重度抑郁症（MD）的主要情绪，在一个前瞻性的、有充分记录的社区样本中，自出生以来一直跟踪。方法：136名儿童（65名男孩和71名女孩）的母亲有不同程度的抑郁症状，使用1.5特斯拉系统对他们进行扫描，同时他们观看了5块悲伤和中性的电影片段。在扫描之后，他们对所经历的情绪进行评级，如果他们确定了悲伤，他们也被要求对其强度进行评级。结果：在母亲表现出较高抑郁症状的儿童中，与母亲表现出较低抑郁症状的儿童相比，在已知与悲伤和抑郁症有关的大脑区域，特别是脑岛、前扣带皮层和尾状核，注意到对悲伤电影片段的神经反应发生了改变，尽管儿童当前的情绪没有差异。局限性：这是否代表遗传易感性或在年轻时暴露于母亲抑郁症状的后果尚不清楚。讨论：该结果与健康成人和MD患者的研究结果一致。目前的研究表明，大脑对悲伤刺激的区域反应模式的改变，在儿童时期就已经存在，并且可能代表了以后生活中患MD的脆弱性。(C) 2011 Elsevier B.V.版权所有
Introduction: We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of sadness, the prevailing mood in major depression (MD), in a prospective, well-documented community sample followed since birth.Methods: The children, comprising 136 children (65 boys and 71 girls) of mothers with varying levels of depressive symptomatology, were scanned - using a 1.5-Tesla system - while they watched 5 blocks of both sad and neutral film excerpts. Following scanning, they rated the emotions they experienced, and if they identified sadness, they were also asked to rate its intensity.Results: In children whose mothers exhibited higher depressive symptomatology, compared to children whose mothers displayed lower depressive symptomatology, altered neural responses to sad film excerpts were noted in brain regions known to be involved in sadness and MD, notably the insula, anterior cingulate cortex and caudate nucleus, even though the children did not differ in current mood.Limitations: Whether this represents genetic vulnerability or a consequence of exposure to maternal depressive symptoms at a young age is unknown.Discussion: The results are consistent with the results of studies in healthy adults and MD patients. The present study suggests that an altered pattern of regional brain responses to sad stimuli, is already present in childhood and might represent vulnerability for MD later in life. (C) 2011 Elsevier B.V. All rights reserved.