Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat.
Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat.
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雷帕霉素，一种强效免疫抑制药物，用于大鼠血管化心脏、肾脏和小肠移植。
DOI：
10.1097/00007890-199101000-00002
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发表时间：
1991
期刊：
影响因子：
6.2
通讯作者：
Kahan,BD
中科院分区：
文献类型：
--
作者：
Stepkowski,SM;Chen,H;Daloze,P;Kahan,BD
雷帕霉素（RAPA）的有效性进行了检查心脏，肾脏和小肠同种异体移植大鼠。未处理或仅输注溶剂的Wistar Furth（RT 1u）受体在平均存活时间（MST）分别为6.5+/-0.5天和6.3+/-0.5天内排斥布法罗（RT 1b）心脏同种异体移植物。相比之下，通过渗透泵向WFu受体连续静脉（iv）输注0.08 mg/kg/天RAPA 14天，将BUF心脏移植物存活期延长至34.4+/-12.1天（P= 0.0001）。0.16 mg/kg（39.0+/-8.7天; P= 0.0001）、0.32 mg/kg（55.7+/-3.3天; P= 0.0001）和0.8 mg/kg（48.0+/-3.6; P= 0.0001）的剂量反应分级。此外，0.02 mg/kg/天的动脉内/移植物内输注（而非静脉输注）延长了BUF同种异体心脏移植物，即MST分别为14.6+/-1.4天vs 8.6+/-2.6天（P= 0.0001）。RAPA的局部递送剂量与静脉内递送的相同剂量一样有效：0.08 mg/kg MST 37.0+/-18.3天（P= 0.0001）; 0.32 mg/kg，40.0+/-3.9天（P= 0.0001）;和0.8 mg/kg，54.8+/-8.2天（P= 0.0001）。
The effectiveness of rapamycin (RAPA) was examined for heart, kidney, and small bowel allografts in rats. Untreated or vehicle only-infused Wistar Furth (RT1u) recipients rejected Buffalo (RT1b) heart allografts within a mean survival time (MST) of 6.5+/-0.5 and 6.3+/-0.5 days, respectively. In contrast, a 14-day continuous intravenous (iv) infusion by an osmotic pump of 0.08 mg/kg/day RAPA to WFu recipients prolonged BUF heart allograft survival to an MST of 34.4+/-12.1 days (P= 0.0001). There was a graded dose-response to 0.16 mg/kg (39.0+/-8.7 days; P= 0.0001), 0.32 mg/kg (55.7+/-3.3 days; P= 0.0001) and 0.8 mg/kg (48.0+/-3.6; P= 0.0001). Furthermore, intraarterial/intragraft but not iv infusion of 0.02 mg/kg/day prolonged BUF heart allografts-namely, an MST of 14.6+/-1.4 days versus 8.6+/-2.6 days (P= 0.0001), respectively. Local delivery doses of RAPA were about as effective as the same dose delivered iv: 0.08 mg/kg MST 37.0+/-18.3 days (P= 0.0001); 0.32 mg/kg, 40.0+/-3.9 days (P= 0.0001); and 0.8 mg/kg, 54.8+/-8.2 days (P= 0.0001).