Altered cortical-amygdala coupling in social anxiety disorder during the anticipation of giving a public speech.
Altered cortical-amygdala coupling in social anxiety disorder during the anticipation of giving a public speech.
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DOI：
10.1017/s0033291714002657
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发表时间：
2015-05
影响因子：
6.9
通讯作者：
Roelofs K
中科院分区：
文献类型：
--
作者：
Cremers HR;Veer IM;Spinhoven P;Rombouts SA;Yarkoni T;Wager TD;Roelofs K
社交情境中的严重压力是社交焦虑障碍的核心症状。杏仁核和皮质区域之间的连接被认为对情绪调节很重要，而这种功能在SAD中受到损害。然而，在压力诱导的社会评价威胁条件下，这种连接模式是否以及如何变化，从未被测试过。在这里，我们研究了在预期发表公开演讲时SAD中皮质-杏仁核偶联的变化。20名SAD患者和年龄、性别和教育程度相匹配的对照组（n = 20）参加了这项研究。在功能磁共振成像（fMRI）期间，参与者接受了三次“静息状态”的fMRI扫描：一次是在预期发表公开演讲之前，一次是在演讲期间，一次是在演讲之后。研究了皮层情绪调节区与杏仁核之间的功能连接。与对照组相比，SAD参与者在公开演讲预期期间表现出皮层情绪调节区域和杏仁核之间功能整合的减少。此外，SAD参与者的皮质-杏仁核连通性变化与社交焦虑症状严重程度相关。皮层-杏仁核连接的独特模式表明，在社交应激情境下，SAD患者的皮层-皮层下通信不太有效。
Severe stress in social situations is a core symptom of social anxiety disorder (SAD). Connectivity between the amygdala and cortical regions is thought to be important for emotion regulation, a function that is compromised in SAD. However, it has never been tested if and how this connectivity pattern changes under conditions of stress-inducing social evaluative threat. Here we investigate changes in cortical-amygdala coupling in SAD during the anticipation of giving a public speech. Twenty individuals with SAD and age-, gender- and education-matched controls (n = 20) participated in this study. During the functional magnetic resonance imaging (fMRI) session, participants underwent three ‘resting-state’ fMRI scans: one before, one during, and one after the anticipation of giving a public speech. Functional connectivity between cortical emotion regulation regions and the amygdala was investigated. Compared to controls, SAD participants showed reduced functional integration between cortical emotion regulation regions and the amygdala during the public speech anticipation. Moreover, in SAD participants cortical-amygdala connectivity changes correlated with social anxiety symptom severity. The distinctive pattern of cortical-amygdala connectivity suggests less effective cortical-subcortical communication during social stress-provoking situations in SAD.