Dietary total antioxidant capacity (TAC) among candidates for coronary artery bypass grafting (CABG) surgery: Emphasis to possible beneficial role of TAC on serum vitamin D
Dietary total antioxidant capacity (TAC) among candidates for coronary artery bypass grafting (CABG) surgery: Emphasis to possible beneficial role of TAC on serum vitamin D
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DOI：
10.1371/journal.pone.0208806
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发表时间：
2018-12-12
期刊：
影响因子：
3.7
通讯作者：
Najafi, Mandi
中科院分区：
文献类型：
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作者：
Farhangi, Mandieh Abbasalizad;Najafi, Mandi
目的近年来，总抗氧化能力（TAC）的临床重要性及其对心血管疾病、骨质疏松症和多种癌症等慢性疾病的保护作用已被报道。然而，其与冠状动脉旁路移植术（CABG）患者中的心脏代谢危险因素的相关性尚未得到评估。冠状动脉旁路移植术是与增加氧化应激和自由基，所以，目前的研究是为了评估潜在的关联TAC与心血管危险因素之间的患者候选人为CABG.Methods和materialsIn当前的横断面研究，454例患者年龄35-80岁的候选人的冠状动脉旁路移植术和住院德黑兰心脏中心。从所有参与者中获得人体测量和人口统计学特征。根据半定量食物频率问卷（FFQ）的结果计算总膳食抗氧化能力（TAC）。生化参数，包括血脂，白蛋白，肌酐，HbA 1C，C-反应蛋白（CRP），脂蛋白（a），肌酐，血尿素氮（BUN）和血清维生素D浓度也进行了评估，通过商业实验室methods. ResultsThe男性患者在TAC的前五分之一有显着降低高血压的患病率（35.1%比45.9%）。此外，与最低五分位数相比，TAC第五个五分位数的男性患者血清维生素D浓度高出2%，血清胆固醇浓度低3%。与最低的五分位数相比，TAC最高的五分位数使患者更可能具有低红细胞压积和高血清白蛋白浓度（P < 0.05）。然而，在女性参与者中，只有血清肌酐浓度与TAC呈负相关。在比较的临床参数，女性在第五个五分之一的TAC有9%以上的EF相比，患者在第一个五分之一（P = 0.021）。结论我们的研究结果，较高的饮食抗氧化能力与较低的高血压患病率，较低的红细胞压积，总胆固醇和较高的白蛋白和维生素D浓度。因此，高膳食TAC可被认为是一种有效的保护工具，对心脏代谢危险因素的患者，特别是男性患者的CABG候选人。
AimsRecently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG.Methods and materialsIn the current cross-sectional study, 454 patients aged 35-80 years as candidates of CABG and hospitalized in Tehran Heart Center were enrolled. Anthropometric and demographic characteristics were obtained from all participants. Total dietary antioxidant capacity (TAC) was calculated according to the findings of semi-quantitative food-frequency questionnaire (FFQ). Biochemical parameters including serum lipids, albumin, creatinine, HbA1C, C-reactive protein (CRP), lipoprotein (a), creatinine, blood urea nitrogen (BUN) and serum vitamin D concentrations were also assessed by commercial laboratory methods.ResultsMale patients in the top quintiles of TAC had significantly lower prevalence of hypertension (35.1% vs 45.9%). Moreover, male patients at fifth quintile of TAC were 2% more serum vitamin D concentrations, 3% lower serum cholesterol concentrations compared with lowest quintile. Top quintiles of TAC make patients more likely to have low hematocrit and high serum albumin concentrations compared with lowest quintiles (P < 0.05). However, in female participants, only serum creatinine concentration was in negative association with TAC. In comparison of clinical parameters, females in the fifth quintile of TAC had 9% higher EF compared with patients in the first quintile (P = 0.021).ConclusionTo our findings, higher dietary antioxidant capacity was associated with lower prevalence of hypertension, lower hematocrit, total cholesterol and higher albumin and vitamin D concentrations. Therefore, high dietary TAC could be considered as a potent protective tool against cardio-metabolic risk factors in patients CABG candidate for especially in male patients.