Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives
Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives
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DOI：
10.1016/j.bmcl.2008.05.109
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发表时间：
2008-07-15
影响因子：
2.7
通讯作者：
Tokuda, Harukuni
中科院分区：
文献类型：
--
作者：
Koyama, Junko;Nisino, Yu;Tokuda, Harukuni
作为使用天然和合成产物作为癌症化学预防剂的研究的延续，我们使用循环伏安法来检查从大黄素在磷酸盐缓冲液中在pH 7.2制备的甲基化大黄素衍生物的还原-氧化电位。甲基化大黄素衍生物对EB病毒早期抗原（EBV-EA）活化的抑制作用与其还原电位之间存在良好的相关性。此外，EBV-EA活化与包括甲基化大黄素衍生物在内的35种蒽醌衍生物的还原潜力之间存在显着相关性。进一步表明，可以通过包括LUMO能量和羟基基团的数目作为附加参数来增强相关性。(c)2008爱思唯尔有限公司保留所有权利。
As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction-oxidation potentials of methylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2. A good correlation was found between the inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation and the reduction potential of methylated emodin derivatives. Furthermore, there was significant correlation between EBV-EA activation and the reduction potential of 35 anthraquinone derivatives including methylated emodin derivatives. It was further shown that the correlation could be enhanced by including LUMO energy and the number of hydroxy groups as additional parameters. (c) 2008 Elsevier Ltd. All rights reserved.