Relative Flow Reserve Derived From Quantitative Perfusion Imaging May Not Outperform Stress Myocardial Blood Flow for Identification of Hemodynamically Significant Coronary Artery Disease
Relative Flow Reserve Derived From Quantitative Perfusion Imaging May Not Outperform Stress Myocardial Blood Flow for Identification of Hemodynamically Significant Coronary Artery Disease
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DOI：
10.1161/circimaging.114.002400
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发表时间：
2015-01-01
影响因子：
7.5
通讯作者：
Knaapen, Paul
中科院分区：
文献类型：
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作者：
Stuijfzand, Wijnand J.;Uusitalo, Valtteri;Knaapen, Paul
背景：定量心肌灌注成像越来越多地用于冠状动脉疾病的诊断。定量灌注成像可以无创地计算血流储备分数（FFR）。这种所谓的相对血流储备（RFR）被定义为狭窄区域充血心肌血流（MBF）与正常灌注区域充血心肌血流（MBF）的比值。本研究的目的是评估RFR在检测重大冠状动脉疾病中的价值。方法和结果：对疑似冠状动脉疾病的临床患者进行氧-15标记水心脏正电子发射断层扫描和有创冠状动脉造影，包括92例单血管或双血管疾病患者。中度病变（直径狭窄，30%-90%;n=75）采用FFR检查。38支（41%）血管血流动力学显著（> - 90%狭窄或FFR）
Background-Quantitative myocardial perfusion imaging is increasingly used for the diagnosis of coronary artery disease. Quantitative perfusion imaging allows to noninvasively calculate fractional flow reserve (FFR). This so-called relative flow reserve (RFR) is defined as the ratio of hyperemic myocardial blood flow (MBF) in a stenotic area to hyperemic MBF in a normal perfused area. The aim of this study was to assess the value of RFR in the detection of significant coronary artery disease.Methods and Results-From a clinical population of patients with suspected coronary artery disease who underwent oxygen-15-labeled water cardiac positron emission tomography and invasive coronary angiography, 92 patients with single- or 2-vessel disease were included. Intermediate lesions (diameter stenosis, 30%-90%; n=75) were interrogated by FFR. Thirty-eight (41%) vessels were deemed hemodynamically significant (>90% stenosis or FFR