L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.
L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.
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L-天冬氨酸：鲤鱼视网膜视锥光感受器突触传递中作用的证据。
DOI：
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发表时间：
1978
影响因子：
11.1
通讯作者：
J. Dowling
中科院分区：
文献类型：
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作者：
S. M. Wu;J. Dowling
本实验将一系列可能的神经递质及其拮抗剂应用于鲤鱼视网膜，同时进行L型视锥水平细胞的细胞内记录。在所有测试的物质中，L-天冬氨酸被认为是在暗适应、部分光适应和Co2+处理的视网膜中去极化这些水平细胞的最有效的药剂。此外，DL-α-氨基己二酸，L-天冬氨酸拮抗剂，阻断了内源性光感受器递质和外源性L-天冬氨酸对水平细胞的影响。结果表明，L-天冬氨酸和天然递质相互作用的水平细胞膜上的突触后受体的相同人口。
A number of putative neurotransmitter substances and their antagonists were applied to the carp retina while intracellular recordings from L-type cone horizontal cells were made. Of all the substances tested, L-aspartate was found to be the most potent agent in depolarizing these horizontal cells in dark-adapted, partially light-adapted, and Co2+-treated retinas. Furthermore, DL-alpha-aminoadipate, an L-aspartate antagonist, blocked the effects of both the endogenous photoreceptor transmitter and exogenously applied L-aspartate on the horizontal cells. The results suggest that L-aspartate and the natural transmitter interact with the same population of postsynaptic receptors in the horizontal cell membrane.