HIGH-FREQUENCY EXCISION OF TRANSPOSABLE ELEMENT TC1 IN THE NEMATODE CAENORHABDITIS ELEGANS IS LIMITED TO SOMATIC-CELLS
HIGH-FREQUENCY EXCISION OF TRANSPOSABLE ELEMENT TC1 IN THE NEMATODE CAENORHABDITIS ELEGANS IS LIMITED TO SOMATIC-CELLS
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DOI：
10.1016/0092-8674(84)90339-8
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发表时间：
1984-01-01
期刊：
影响因子：
64.5
通讯作者：
YESNER, L
中科院分区：
文献类型：
--
作者：
EMMONS, SW;YESNER, L
线虫秀丽隐杆线虫中的TC1转座元素以高频进行切除。这种切除主要发生在生物体的体细胞组织中。通过证明TC1元素在遗传上稳定来证明缺乏种系切除。在连续的，非选择性传播的一年中，特定基因组部位的元素以及基因组中的总体数量稳定。通过证明在同步种群的单一生长中出现空的TC1位点，可以证明体细胞切除，并且未经下一代遗传。 TC1元素的切除可能在组织特异性因素的控制之下。
Tc1 transposable elements in the nematode C. elegans undergo excision at high frequency. This excision occurs primarily or entirely in the somatic tissues of the organism. Absence of germ-line excision is demonstrated by showing that Tc1 elements are genetically stable; elements at particular genomic sites, as well as the overall number of elements in the genome, were stably maintained during a year of continuous, nonselective propagation. Somatic excision is demonstrated by showing that empty Tc1 sites arise during a single generation of growth of a synchronous population and are not inherited by the next generation. Excision of Tc1 elements probably is under the control of tissue-specific factors.