Functional affinity of antibody to the Haemophilus influenzae type b polysaccharide.

Functional affinity of antibody to the Haemophilus influenzae type b polysaccharide.
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抗体与 b 型流感嗜血杆菌多糖的功能亲和力。

DOI:
10.1093/infdis/159.6.1083
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发表时间:
1989
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Garcia,G
Garcia,G
中科院分区:
--
文献类型:
--
作者:
Griswold,WR;Lucas,AH;Bastian,JF;Garcia,G

文献摘要

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The functional affinity, or avidity, of antibody to the capsular polysaccharide ofHaemophilus influenzae(Hib-PS) was measured in serum samples from 12 adult male subjects before and after immunization with Hib-PS vaccine. Mean avidity increased from 0.74 nM−1to 1.5 nM−1after immunization (P< .05, paired Student'sttest). The Bureau of Biologics reference antiserum had an avidity constant of 12nM−1, which was the highest of all 25 serum samples studied.