The tethered aminohydroxylation (TA) reaction
The tethered aminohydroxylation (TA) reaction
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DOI：
10.1039/b305189g
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发表时间：
2003-01-01
影响因子：
3.2
通讯作者：
Pye, RJ
中科院分区：
文献类型：
--
作者：
Donohoe, TJ;Johnson, PD;Pye, RJ
自从 Sharpless 发现不对称氨基羟基化 (AA) 反应以来，化学家面临的一个主要挑战是找到控制这一重要反应的区域化学和立体化学结果的方法。本文详细介绍了我们通过使用束缚氨基甲酸酯促进分子内 AA 反应来获得可靠且可预测的区域和立体控制的新方法，并描述了为这种新方法提出的机制。
Since Sharpless' discovery of the asymmetric aminohydroxylation ( AA) reaction, a major challenge for chemists has been to find ways of controlling the regio- and stereochemical outcome of this important reaction. Detailed herein is a review of our novel approach towards gaining reliable and predictable regio- and stereocontrol through the use of a tethered carbamate to promote an intramolecular AA reaction, along with a description of the mechanism proposed for this new methodology.