Racial differences in the prevalence of age-related macular degeneration - The Baltimore eye survey
Racial differences in the prevalence of age-related macular degeneration - The Baltimore eye survey
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DOI：
10.1016/s0161-6420(99)90267-1
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发表时间：
1999-06-01
期刊：
影响因子：
13.7
通讯作者：
Tielsch, JM
中科院分区：
文献类型：
--
作者：
Friedman, DS;Katz, J;Tielsch, JM
目的：在东巴尔的摩40岁或以上的黑人和白人人群样本中，确定年龄相关性黄斑变性（AMD）的患病率和年龄相关性黄斑病变的体征。设计：基于人群的横断面研究。参与者：共有5308名黑人和白色受试者接受了包括眼底照相在内的筛选性眼科检查。主要结果测量：立体彩色眼底照片根据黄斑玻璃疣、色素异常、地图状萎缩和脉络膜新生血管的存在和严重程度进行分级。在两组中，约20%的个体中确定了大于或等于64 μ m的玻璃疣，但较大的玻璃疣（>125 μ m）在老年白人中更为常见（70岁以上的白人为15%，黑人为9%）。色素异常在老年白人中也更常见（70岁以上的白人为7.9%，黑人为0.4%）。视网膜相关性黄斑变性在白人和黑人中更为普遍。在70岁以上的白人中，AMD的患病率为2.1%。在这个年龄组的243名黑人受试者中没有检测到AMD病例。Logistic回归调整年龄，性别和吸烟（当前，以前，或从来没有）检测到的优势比为4.4（95%置信区间：1.5-12.4）为白人与AMD相比blacks.Conclusion：虽然玻璃疣是常见的黑人和白人超过40岁，更严重的形式的年龄相关性黄斑病变和晚期AMD更普遍的老年白人。
Objective: To determine the prevalence of age-related macular degeneration (AMD) and signs of age-related maculopathy in a population-based sample of blacks and whites 40 years of age or older from East Baltimore.Design: Cross-sectional population-based study.Participants: A total of 5308 black and white subjects received a screening eye examination that included fundus photography.Main Outcome Measures: Stereoscopic color fundus photographs were graded for the presence and severity of drusen, pigmentary abnormalities, geographic atrophy, and choroidal neovascularization in the macula.Results: Drusen greater than or equal to 64 mu m were identified in about 20% of individuals in both groups, but large drusen (>125 mu m) were more common among older whites (15% for whites versus 9% for blacks over 70). Pigmentary abnormalities were also more common among older whites (7.9% for whites versus 0.4% for blacks over 70). Age-related macular degeneration was more prevalent among whites (t)han blacks. The prevalence of AMD was 2.1 % among whites over 70 years of age. No cases of AMD were detected among 243 black subjects in this age group. Logistic regression adjusting for age, sex and smoking (current, former, or never) detected an odds ratio of 4.4 (95% confidence interval: 1.5-12.4) for whites with AMD compared with blacks.Conclusion: Although drusen are common in both blacks and whites over the age of 40, more severe forms of age-related maculopathy and late AMD are more prevalent in older whites.