Natriuretic peptides and right atrial fibrosis in patients with paroxysmal versus persistent atrial fibrillation
Natriuretic peptides and right atrial fibrosis in patients with paroxysmal versus persistent atrial fibrillation
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阵发性房颤与持续性房颤患者的利钠肽和右心房纤维化
DOI：
10.1016/j.peptides.2010.04.019
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发表时间：
2010-08-01
期刊：
影响因子：
3
通讯作者：
Chen, Yijiang
中科院分区：
文献类型：
--
作者：
Cao, Hailong;Xue, Lei;Chen, Yijiang
钠尿肽（NP）是心力衰竭的极好诊断和预后标志物，但其在心房颤动（AF）中的作用，特别是孤立性心脏瓣膜起源的，尚不清楚。我们评估了 30 名阵发性 AF (PaAF) 和 40 名持续性 AF (PeAF) 患者以及 34 名窦性心律 (SR) 患者的血浆中右心耳 (RAA) 中的心房钠尿肽前体 (pro-ANP) 和脑钠尿肽前体 (proBNP) 及其 N 末端片段 (nt-proANP 和 nt-proBNP) 的 mRNA 和蛋白质含量。孤立性瓣膜置换术。为了探索其潜在机制，在 RAA 中同时进行了纤维化相关检查。出乎意料的是，pro-NPs mRNA 的心房表达在 PaAF 亚组中显着增强，但在 PeAF 亚组中不那么明显。心房中 pro-NPs 蛋白和血浆 nt-proNPs 的含量在 PaAF 和 PeAF 亚组中也类似地增加，两者之间存在令人惊讶的强正相关性（pro-ANP 和 nt-proANP：r = 0.918，p < 0.001；pro-BNP 和 nt-proBNP：r = 0.913，p < 0.001）。我们发现 SR 中心房胶原体积分数 (CVF)、胶原蛋白 I 和 III 水平的梯度显着增加。 PaAF 和 PeAF 组，以及 CVF、胶原蛋白 Land III 水平和 pro-NP 心房转录物之间令人信服的负线性相关性。这些结果表明，转录本和pro-NPs蛋白含量之间的不一致可能是由于PeAF中心房纤维化更为突出，循环nt-proNPs水平可以反映本报告中相应的心房pro-NPs含量。 (C) 2010 Elsevier Inc. 保留所有权利。
Natriuretic peptides (NPs) are excellent diagnostic and prognostic markers of heart failure, but their roles in atrial fibrillation (AF), particularly of isolated cardiac valvular origin, are unclear. We assessed the mRNA and protein content of pro-atrial natriuretic peptide (pro-ANP) and pro-brain natriuretic peptide ( proBNP) in right atrial appendages (RAAs) and their N-terminal fragments (nt-proANP and nt-proBNP) in the plasma of 30 patients with paroxysmal AF (PaAF) and 40 patients with persistent AF (PeAF) matched with 34 patients in sinus rhythm (SR) undergoing isolated valvular replacement. To explore the underlying mechanism, fibrosis related examinations were simultaneously carried out in RAAs. Unexpectedly, atrial expression of pro-NPs mRNA was notably augmented in the PaAF subgroup, but not so pronounced in the PeAF subgroup. Atrial content of pro-NPs proteins and plasma nt-proNPs, between which surprisingly strong positive correlations were found (pro-ANP and nt-proANP: r = 0.918, p < 0.001; pro-BNP and nt-proBNP: r = 0.913, p < 0.001), were increased analogously in PaAF and PeAF subgroups. We identified significantly increasing gradients of atrial collagen volume fraction (CVF), levels of collagen I and III in the SR. PaAF and PeAF groups, and convincing negative linear correlations between CVF, levels of collagen land III, and atrial transcripts of pro-NPs. These findings suggest that the discordance between transcripts and protein contents of pro-NPs was possibly due to the more outstanding atrial fibrosis in PeAF, and that circulating nt-proNPs levels could reflect the corresponding atrial pro-NPs contents in this report. (C) 2010 Elsevier Inc. All rights reserved.