A thirteen-year follow-up of respiratory effects of acute exposure to sulfur dioxide
A thirteen-year follow-up of respiratory effects of acute exposure to sulfur dioxide
复制标题
DOI：
10.5271/sjweh.130
复制
发表时间：
1996-06-01
影响因子：
6.3
通讯作者：
Winblad, I
中科院分区：
文献类型：
--
作者：
Piirila, PL;Nordman, H;Winblad, I
目的1977年，9名工人在硫铁矿爆炸中意外接触二氧化硫。事故发生后，对7名男子的肺功能进行了跟踪调查。此前已公布了一项为期四年的后续行动。用力肺活量（FVC）、1秒用力呼气量（FEV（1.0））和最大呼气中段流量（MMEF）在事故后1周下降最大，此后所有这些参数均有所改善，但未达到事故前水平。可逆性支气管阻塞仍存在于3例患者中，并在组胺激发试验中发现阳性反应4例。本文报道了6名男性肺功能随访13年的结果。方法在事故发生后13年，对患者的临床情况、胸部X线、肺功能测定和组胺激发试验进行了研究。结果1名工人的肺功能正常，2名工人表现为阻塞性肺功能障碍，3名工人表现为阻塞性肺功能障碍和限制性肺功能障碍，主要是阻塞性肺功能障碍。在组胺激发试验中，4例患者表现出支气管高反应性，1例几乎有显著反应。由于支气管阻塞的一个病人不能执行的挑战test.Conclusions这13年的随访结果表明，急性炎症性梗阻引起的暴露于二氧化硫留下的后遗症，阻塞性损害的呼吸功能和永久性支气管高反应性。这些患者的临床表现在1985年被命名为“反应性气道功能障碍综合征”（RADS）。其中四名病人亦有慢性支气管炎的病征。
Objectives In 1977, nine men were accidentally exposed to sulfur dioxide in an explosion in a pyrite mine. The lung function of seven men was followed after the accident. A four-year follow-up has been published previously. The greatest decrease in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1.0)), and maximal midexpiratory flow (MMEF) was observed one week after the accident, after which all these parameters improved without reaching the preaccident level. Reversible bronchial obstruction was still present in three patients, and a positive reaction In the histamine challenge test was found for four. In the present paper, the lung function follow-up 13 years after the accident is reported for six men.Methods The patients' clinical condition, chest X-ray, spirometry, and histamine challenge test were studied 13 years after the incident.Results Spirometry was normal in one worker, two displayed obstruction, and three had a combined obstructive and restrictive, mainly obstructive, ventilatory impairment. In the histamine challenge test, four patients showed bronchial hyperreactivity, one with a nearly significant reaction. Because of bronchial obstruction one patient could not perform the challenge test.Conclusions This 13-year follow-up showed that acute inflammatory obstruction caused by exposure to sulfur dioxide left, as sequelae, obstructive impairment of ventilatory function and permanent bronchial hyperreactivity. The clinical picture displayed by these patients was named the ''reactive airways dysfunction syndrome'' (RADS) in 1985. Four of the patients also showed symptoms of chronic bronchitis.