White matter microstructure alterations in primary dysmenorrhea assessed by diffusion tensor imaging.
White matter microstructure alterations in primary dysmenorrhea assessed by diffusion tensor imaging.
复制标题
通过扩散张量成像评估原发性痛经的白质微结构改变
DOI：
10.1038/srep25836
复制
发表时间：
2016-05-10
影响因子：
4.6
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
Liu P;Wang G;Liu Y;Yu Q;Yang F;Jin L;Sun J;Yang X;Qin W;Calhoun VD
原发性痛经（PDM）是青少年和年轻妇女面临的一个重大公共卫生问题，其特点是痛经。近年来的神经影像学研究表明，脑功能和结构异常与PDM的发病机制有关。然而，尚不清楚PDM中是否存在白质（WM）改变。我们分析了35名患者和35名年龄和惯用手相匹配的健康对照（hc）的弥散张量成像数据。利用基于通道的空间统计和概率通道成像技术测量WM微结构的完整性。与hc相比，患者的分数各向异性（FA）增加，胼胝体（CC）、上纵束（LF）、放射状冠（CR）、内囊（IC）和外囊（EC）的平均弥漫性（MD）和径向弥漫性（RD）降低。患者组脾CC和右侧IC的FA与PDM持续时间呈正相关，右前CR的FA与PDM严重程度呈正相关。通过脑束造影发现，这些脑束与其他涉及感觉运动、情感、认知和疼痛处理功能的大脑区域存在联系。这些发现为PDM中WM微观结构的改变提供了初步证据，对理解PDM的病理机制具有潜在的价值。
Primary dysmenorrhea (PDM), a significant public health problem for adolescents and young women, is characterized by painful menstrual cramps. Recent neuroimaging studies have revealed that brain functional and structural abnormalities are related to the pathomechanism of PDM. However, it is not clear whether there are white matter (WM) alterations in PDM. We analyzed diffusion tensor imaging data from 35 patients and 35 healthy controls (HCs) matched for age and handedness. Tract-based spatial statistics and probabilistic tractography were used to measure integrity of WM microstructure. Compared to HCs, patients had increased fractional anisotropy (FA) along with decreased mean diffusivity (MD) and radial diffusivity (RD) in the corpus callosum (CC), superior longitudinal fasciculus (LF), corona radiata (CR), internal capsule (IC) and external capsule (EC). The FA of the splenium CC and right IC positively correlated with PDM duration while FA of the right anterior CR positively correlated with PDM severity in patient group. These WM tracts were found to show connections to other brain regions implicated in sensoimotor, affective, cognitive and pain processing functions through tractography. These findings provide preliminary evidence for WM microstructure alterations in PDM, which is potentially valuable for understanding pathomechanism of PDM.