Gradient generation platforms: new directions for an established microfluidic technology.

Gradient generation platforms: new directions for an established microfluidic technology.
复制标题

梯度生成平台:已建立微流体技术的新方向。

DOI:
10.1039/c4lc00448e
复制
发表时间:
2014-09-07
期刊:
影响因子:
6.1
通讯作者:
Beebe DJ
Beebe DJ
中科院分区:
工程技术1区
文献类型:
--
作者:
Berthier E;Beebe DJ

文献摘要

参考文献

被引文献

相似文献

微尺度平台使基于细胞的研究成为可能,因为它们允许再现生理条件,例如细胞外基质(ECM)构型和可溶性因子相互作用。梯度生成平台是微流体技术的少数几个应用之一,已经开始被转移到生物实验室,并可能成为新的“黄金标准”。虽然梯度生成平台现已建立,但其全部潜力尚未实现。在这里,我们将提供我们对梯度生成和细胞迁移平台发展中取得的里程碑的看法,以及新兴的方向,如使用细胞迁移作为诊断读出和从细胞迁移模型中获得机制信息。
Microscale platforms are enabling for cell-based studies as they allow the recapitulation of physiological conditions such as extracellular matrix (ECM) configurations and soluble factors interactions. Gradient generation platforms have been one of the few applications of microfluidics that have begun to be translated to biological laboratories and may become a new “gold standard”. Though gradient generation platforms are now established, their full potential has not yet been realized. Here, we will provide our perspective on milestones achieved in the development of gradient generation and cell migration platforms, as well as emerging directions such as using cell migration as a diagnostic readout and attaining mechanistic information from cell migration models.
DOI: 10.1039/c0ib00011f
发表时间: 2010-01-01
影响因子: 2.5
作者:
Ambravaneswaran, Vijayakrishnan;Wong, Ian Y.;Irimia, Daniel
通讯作者: Irimia, Daniel
DOI: 10.1039/c4ib00015c
发表时间: 2014-05
期刊: Integrative biology : quantitative biosciences from nano to macro
影响因子: --
作者:
Cavnar SP;Ray P;Moudgil P;Chang SL;Luker KE;Linderman JJ;Takayama S;Luker GD
通讯作者: Luker GD
DOI: 10.1039/c3ib40240a
发表时间: 2014-01-01
影响因子: 2.5
作者:
Bischel, Lauren L.;Casavant, Benjamin P.;Beebe, David J.
通讯作者: Beebe, David J.
DOI: 10.1063/1.3490784
发表时间: 2010-12-01
期刊: BIOMICROFLUIDICS
影响因子: 3.2
作者:
Cate, David M.;Sip, Christopher G.;Folch, Albert
通讯作者: Folch, Albert
DOI: 10.1083/jcb.200810041
发表时间: 2009-02-23
期刊: The Journal of cell biology
影响因子: --
作者:
Doyle AD;Wang FW;Matsumoto K;Yamada KM
通讯作者: Yamada KM