Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in vivo
Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in vivo
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DOI：
10.1038/s41598-020-70876-4
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发表时间：
2020-08-18
影响因子：
4.6
通讯作者：
Nikuni，Tetsuro
中科院分区：
文献类型：
--
作者：
Hata，Katsuhiko;Araki，Osamu;Nikuni，Tetsuro
神经信息处理的两个要素主要被提出：神经元的放电率和发放时间。在突触可塑性的情况下，虽然尖峰时间依赖可塑性（STDP）依赖于突触前和突触后的尖峰时间被认为是最常见的规则，最近的研究表明，在体内的大脑的抑制性质精确的尖峰时间，这是关键的STDP。因此，放电频率在体内突触可塑性中的重要性再次被认识。然而，很少有人知道频率依赖性突触可塑性（FDP）是如何在体内调节。在这里，我们专注于突触前输入模式，细胞内钙衰减时间常数，和背景突触活动，这取决于神经元类型和大脑中的解剖和生理环境。通过分析基于钙的模型，我们发现，突触的重量取决于这些因素的特点在体内，即使神经元接收相同的输入速率。这一发现表明，在FDP，甚至在体内的神经编码的输入频率以外的多方面因素的参与。
Two elements of neural information processing have primarily been proposed: firing rate and spike timing of neurons. In the case of synaptic plasticity, although spike-timing-dependent plasticity (STDP) depending on presynaptic and postsynaptic spike times had been considered the most common rule, recent studies have shown the inhibitory nature of the brain in vivo for precise spike timing, which is key to the STDP. Thus, the importance of the firing frequency in synaptic plasticity in vivo has been recognized again. However, little is understood about how the frequency-dependent synaptic plasticity (FDP) is regulated in vivo. Here, we focused on the presynaptic input pattern, the intracellular calcium decay time constants, and the background synaptic activity, which vary depending on neuron types and the anatomical and physiological environment in the brain. By analyzing a calcium-based model, we found that the synaptic weight differs depending on these factors characteristic in vivo, even if neurons receive the same input rate. This finding suggests the involvement of multifaceted factors other than input frequency in FDP and even neural coding in vivo.