Type 2 diabetes - Tuberculosis co-morbidity is associated with diminished circulating levels of IL-20 subfamily of cytokines.
Type 2 diabetes - Tuberculosis co-morbidity is associated with diminished circulating levels of IL-20 subfamily of cytokines.
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DOI：
10.1016/j.tube.2015.06.004
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Babu S
中科院分区：
文献类型：
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作者：
Kumar NP;Banurekha VV;Nair D;Kumaran P;Dolla CK;Babu S
IL-20亚家族细胞因子在机体防御机制和糖代谢中起重要作用。由于结核病（TB）和糖尿病（DM）之间的相互作用涉及上述两个过程，我们研究了IL-20亚家族细胞因子在TB-DM共病中的相关性。我们检测了活动性TB伴（PTB-DM）或不伴（PTB）糖尿病个体以及潜伏性TB伴（LTB-DM）或不伴（LTB）糖尿病个体的循环血浆细胞因子水平。PTB-DM的特征在于IL-19、IL-20、IL-22和IL-24的循环水平降低，但IL-10的水平升高。类似地，LTB-DM的特征还在于IL-10、IL-19、IL-20和IL-24的循环水平降低，但IL-22的水平升高。此外，在PTB和/或LTB个体中，IL-10、IL-19、IL-20、IL-22和IL-24水平与血红蛋白A1 C（HbA 1c）水平呈显著负相关。最后，PTB的特征在于与LTB个体相比IL-19、IL-20、IL-22和IL-24的水平降低。我们的数据显示，无论是PTB或LTB并发糖尿病的特点是减少生产的IL-20亚家族的细胞因子，并建议这些细胞因子可能发挥重要作用的发病机制或保护。
IL-20 subfamily of cytokines play an important role in both host defense mechanisms and glucose metabolism. Since, the interaction between tuberculosis (TB) and diabetes (DM) involves both of the above processes, we examined the association of IL-20 subfamily of cytokines in TB-DM co-morbidity. We examined circulating plasma cytokine levels in individuals with active TB with (PTB-DM) or without (PTB) diabetes and also those with latent TB with (LTB-DM) or without (LTB) diabetes. PTB-DM is characterized by diminished circulating levels of IL-19, IL-20, IL-22 and IL-24 but increased levels of IL-10. Similarly, LTB-DM was also characterized by diminished circulating levels of IL-10, IL-19, IL-20 and IL-24 but increased levels of IL-22. Moreover, there was a significant negative correlation of IL-10, IL-19, IL-20, IL-22 and IL-24 levels with hemoglobin A1C (HbA1c) levels in both PTB and/or LTB individuals. Finally, PTB is characterized by diminished levels of IL-19, IL-20, IL-22 and IL-24 in comparison to LTB individuals. Our data reveal that coincident diabetes in either PTB or LTB is characterized by decreased production of the IL-20 subfamily of cytokines and suggest that these cytokines might play an important role in pathogenesis or protection.