Control of insulin permeation through a polymer membrane with responsive function for glucose
Control of insulin permeation through a polymer membrane with responsive function for glucose
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通过具有葡萄糖响应功能的聚合物膜控制胰岛素渗透
DOI：
10.1002/marc.1983.030040511
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Isao Shionohara
中科院分区：
文献类型：
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作者：
K. Ishihara;M. Kobayashi;Isao Shionohara
由聚合物材料组成的药物缓释系统已被许多研究人员研究，以防止由于药物在身体局部持续作用而导致的药物过量。在这样的体系中，聚合物基质的渗透性是药物释放曲线的主要因素，它取决于聚合物的性质，如疏水性、电荷和密度。为了开发一种更理想的药物释放系统，需要使用一种对外部刺激具有响应功能的聚合物。我们已经研究了药物在特定刺激(如氨基化合物浓度的变化)或光照射下的释放规律。在体内，胰腺会根据血液中葡萄糖的浓度释放胰岛素。本文介绍了一种能够调节胰岛素释放以响应葡萄糖浓度变化的聚合物膜的制备。这种葡萄糖响应型聚合物膜由两个聚合物膜组成。一种膜是含有葡萄糖氧化酶(GOD)的聚丙烯酰胺膜，GOD作为葡萄糖的传感器，通过酶反应形成过氧化氢。另一层膜是具有烟酰胺部分的氧化还原聚合物，该部分通过与过氧化氢的氧化反应来调节胰岛素的渗透速率。
Slow release systems of drug consisting of polymeric materials have been studied by many investigators to prevent over-dosage of drug due to continuous effects of the drug at local areas of the body'). In such a system, the permeability of the polymer matrix, which depends on the nature of the polymer such as hydrophobicity, electric charge, and density, is a dominant factor for the release profile of drug. In order to develop a more ideal release system of drug, a polymer with a responsive function for external stimulation should be applied. We have investigated the regulation of drug release in response to a specific stimulation, eg the change in the concentration of amino compounds*) or light irradiations. In the body, the pancreas releases insulin in response to the concentration of glucose in the blood. This paper describes the preparation of a polymer membrane with the ability to regulate the release of insulin in response to the change in the concentration of glucose. This glucose responsive polymeric membrane is constituted by two polymer membranes. One membrane is a polyacrylamide membrane containing glucose oxidase (GOD), which acts as a sensor of glucose and forms hydrogen peroxide by enzymic reaction. The other membrane is a redox polymer having a nicotinamide moiety which acts as a regulator of the permeation rate of insulin by means of an oxidation reaction with the hydrogen peroxide.